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Kidney Transplantation From Brain-Dead Donors With Hepatitis B or C in South Korea: A 2015 to 2020 Korean Organ Transplantation Registry Data Analysis
- Title
- Kidney Transplantation From Brain-Dead Donors With Hepatitis B or C in South Korea: A 2015 to 2020 Korean Organ Transplantation Registry Data Analysis
- Authors
- Baik; Seungmin; Kim; Myoung Soo; Yang; Jaeseok; Jeong; Jong Cheol; Koo; Tai Yeon; Deok-Gie; Hoonsung; Jae-Myeong; Lee; Hanyoung; Park
- Ewha Authors
- 백승민
- SCOPUS Author ID
- 백승민
- Issue Date
- 2024
- Journal Title
- Transplantation Proceedings
- ISSN
- 0041-1345
- Citation
- Transplantation Proceedings vol. 56, no. 1, pp. 1 - 9
- Publisher
- Elsevier Inc.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: According to the current Center for Korean Network for Organ Sharing guidelines for kidney transplantation from brain-dead donors with hepatitis B or C infection, organs from hepatitis B surface antigen-positive (HbsAg+) or anti-hepatitis C virus-positive (HCV+) donors can only be transplanted into HBsAg+ or anti-HCV+ recipients. We aimed to confirm the status and the outcomes of kidney transplantation from brain-dead donors with hepatitis B or C virus in Korea. Methods: This retrospective study included all kidney transplantations from brain-dead donors in the Korean Organ Transplantation Registry database between January 2015 and June 2020, divided into 3 groups according to donor hepatitis status. Finally, kidney transplantations from 80 HBV+, 12 HCV+, and 2013 HBV–/HCV– donors were included. Results: No statistically significant differences were observed in the recipient characteristics and the transplant outcomes except the waiting time (HBV+ to HBV–/HCV–, P < .001; HCV+ to HBV–/HCV–, P = .10; HBV+ to HCV+ P = .95). Five-year graft survival rates of the HBV+, HCV+, and HBV–/HCV– recipients were 95%, 83%, and 85%, respectively (HBV+ to HCV+, P = .22; HCV+ to HBV–/HCV–, P = .81; HBV+ to HBV–/HCV–, P = .02). Five-year patient survival rates of the HBV+, HCV+, and HBV–/HCV– recipients were 95%, 100%, and 76%, respectively (HBV+ to HCV+, P = .61; HCV+ to HBV–/HCV–, P = .13; HBV+ to HBV–/HCV–, P < .001). Conclusion: HBV+/HCV+ brain-dead donor kidney transplantation outcomes were comparable to HBV–/HCV–. South Korea should consider conditionally permitting transplantation from HBV+ or HCV+ donors to HBV– or HCV– recipients to accumulate new data and conduct further studies. © 2023
- DOI
- 10.1016/j.transproceed.2023.11.006
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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