Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이형우 | * |
dc.date.accessioned | 2024-02-15T05:12:05Z | - |
dc.date.available | 2024-02-15T05:12:05Z | - |
dc.date.issued | 2024 | * |
dc.identifier.issn | 1351-5101 | * |
dc.identifier.other | OAK-34663 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267853 | - |
dc.description.abstract | Background and purpose: Cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (SN). However, the clinical significance of SN degeneration remains poorly understood. Methods: This retrospective observational study included patients with acute ischemic stroke in the basal ganglia on initial diffusion-weighted imaging who underwent follow-up diffusion-weighted imaging between 4 and 30 days after symptom onset. SN degeneration was defined as a hyperintensity lesion in the SN observed on diffusion-weighted imaging. We compared functional outcomes at 3 months between patients with and without SN degeneration. A poor outcome was defined as a score of 3–6 (functional dependence or death) on the modified Rankin Scale. Results: Of 350 patients with basal ganglia infarction (median age = 74.0 years, 53.7% male), 125 (35.7%) had SN degeneration. The proportion of functional dependence or death was 79.2% (99/125 patients) in patients with SN degeneration, which was significantly higher than that in those without SN degeneration (56.4%, 127/225 patients, p < 0.001). SN degeneration was more frequent in patients with functional dependence or death (99/226 patients, 43.8%) than in those with functional independence (26/124 patients, 21.0%, p < 0.001). Multivariable logistic regression analysis showed a significant association between SN degeneration and functional dependence or death (odds ratio = 2.91, 95% confidence interval = 1.17–7.21, p = 0.021). Conclusions: The study showed that patients with degeneration of SN were associated with functional dependence or death at 3 months, suggesting that secondary degeneration is a predictor of poor stroke outcomes and a potential therapeutic target. © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc | * |
dc.subject | basal ganglia | * |
dc.subject | outcome | * |
dc.subject | prognosis | * |
dc.subject | secondary degeneration | * |
dc.subject | substantia nigra | * |
dc.title | Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | European Journal of Neurology | * |
dc.identifier.doi | 10.1111/ene.16111 | * |
dc.identifier.scopusid | 2-s2.0-85175431668 | * |
dc.author.google | Lee | * |
dc.author.google | Hyungwoo | * |
dc.author.google | Kijeong | * |
dc.author.google | Kim | * |
dc.author.google | Young Dae | * |
dc.author.google | Nam | * |
dc.author.google | Hyo Suk | * |
dc.author.google | Hye Sun | * |
dc.author.google | Cho | * |
dc.author.google | Sunghee | * |
dc.author.google | Heo | * |
dc.author.google | Ji Hoe | * |
dc.contributor.scopusid | 이형우(57209973874) | * |
dc.date.modifydate | 20240502145036 | * |