Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김한수 | * |
dc.date.accessioned | 2024-02-15T05:12:05Z | - |
dc.date.available | 2024-02-15T05:12:05Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1742-7061 | * |
dc.identifier.issn | 1878-7568 | * |
dc.identifier.other | OAK-34661 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267851 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic inflammatory disorder that results in the deterioration of joint cartilage and bone. Toll-like receptor 4 (TLR4) has been pinpointed as a key factor in RA-related inflammation. While Toll-like receptor antagonizing peptide 2 (TAP2) holds potential as an anti-inflammatory agent, its in vivo degradation rate hinders its efficacy. We engineered depots of TAP2 encapsulated in click-crosslinked hyaluronic acid (TAP2+Cx-HA) for intra-articular administration, aiming to enhance the effectiveness of TAP2 as an anti-inflammatory agent within the joint cavity. Our data demonstrated that FI-TAP2+Cx-HA achieves a longer retention time in the joint cavity compared to FI-TAP2 alone. Mechanistically, we found that TAP2 interacts with TLR4 on the cell membranes of inflammatory cells, thereby inhibiting the nuclear translocation of NF-kappa B and maintaining it in an inactive cytoplasmic state. In a rat model of RA, the TAP2+Cx-HA formulation effectively downregulated the inflammatory cytokines TNF-alpha and IL-6, while upregulating the anti-inflammatory cytokine IL-10 and the therapeutic protein 14-3-3 zeta. This led to a more rapid restoration of cartilage thickness, increased deposition of glycosaminoglycans, and new bone tissue formation in the regenerated cartilage, in comparison to a single TAP2 treatment after a six-week period. Our results suggest that TAP2+Cx-HA could serve as a potent intra-articular treatment for RA, offering both symptomatic relief and promoting cartilage regeneration. This innovative delivery system holds significant promise for improving the management of RA and other inflammatory joint conditions. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCI LTD | * |
dc.subject | Rheumatoid arthritis | * |
dc.subject | Toll -like receptors -antagonizing peptide | * |
dc.subject | Click-crosslinking hyaluronic acid depot | * |
dc.subject | Intra-articular injection | * |
dc.subject | Prolonged release | * |
dc.title | Enhanced intra-articular therapy for rheumatoid arthritis using click-crosslinked hyaluronic acid hydrogels loaded with toll-like receptor antagonizing peptides | * |
dc.type | Article | * |
dc.relation.volume | 172 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 188 | * |
dc.relation.lastpage | 205 | * |
dc.relation.journaltitle | ACTA BIOMATERIALIA | * |
dc.identifier.doi | 10.1016/j.actbio.2023.10.023|http://dx.doi.org/10.1016/j.actbio.2023.10.023 | * |
dc.identifier.wosid | WOS:001165320200001 | * |
dc.identifier.scopusid | 2-s2.0-85175243238 | * |
dc.author.google | Lee, Soyeon | * |
dc.author.google | Seo, Jiyoung | * |
dc.author.google | Kim, Young Hun | * |
dc.author.google | Ju, Hyeon Jin | * |
dc.author.google | Kim, Shina | * |
dc.author.google | Ji, Yun Bae | * |
dc.author.google | Lee, Hai Bang | * |
dc.author.google | Kim, Han Su | * |
dc.author.google | Choi, Sangdun | * |
dc.author.google | Kim, Moon Suk | * |
dc.contributor.scopusid | 김한수(56509934900) | * |
dc.date.modifydate | 20240502144901 | * |