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Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry
- Title
- Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry
- Authors
- Bucci; Tommaso; Shantsila; Alena; Romiti; Giulio Francesco; Teo; Wee-Siong; Park; Hyung-Wook; Shimizu; Wataru; Mei; Davide Antonio; Tse; Hung-Fat; Proietti; Marco; Chao; Tze-Fan; Lip; Gregory Y. H.; David; Chun-Wah Siu; Yodogawa; Kenji; Tsutsui; Hiroyuki; Mukai; Yasushi; Tomita; Hirofumi; Horiuchi; Daisuke; Hagii; Joji; Aonuma; Kazutaka; Okumura; Yasuo; Goya; Masahiko; Hirao; Kenzo; Ajioka; Masayoshi; Hagiwara; Nobuhisa; Suzuki; Atsushi; Yamane; Teiichi; Ikeda; Takanori; Yuzawa; Hitomi; Satomi; Kazuhiro; Yazaki; Yoshinao; Fukuda; Keiichi; Kobayashi; Yoshinori; Morita; Norishige; Murohara; Toyoaki; Watanabe; Eiichi; Harada; Masahide; Sakagami; Satoru; Saeki; Takahiro; Kusano; Kengo; Miyamoto; Koji; Miyazaki; Shinsuke; Tada; Hiroshi; Inoue; Koichi; Tanaka; Nobuaki; Koretsune; Yukihiro; Abe; Haruhiko; Kihara; Yasuki; Nakano; Yukiko; Akihiko; Yoshiga; Yasuhiro; Sakamoto; Tomohiro; Okumur; Ken; Takahashi; Naohiko; Shinohara; Tetsuji; Soejima; Kyoko; Takagi; Kawamura; Mitsuharu; Munetsugu; Yumi; Kim; Sung-Hwan; Shim; Jae-Min; Uhm; Jae Sun; Im; Sung Il; Par; Hyoung-Seob; Jun Hyung; On; Young Keun; Oh; Il-Young; Shin; Seung Yong; Ko; Jum Suk; Jun Beom; Won; Kelvin Cheok-Keng; Lim; Toon-Wei; Foo; Chen; Shih-Ann; Lin; Yenn-Jiang; Chung; Fa-Po; Hu; Yu-Feng; Chang; Shil-Lin; Tuan; Ta-Chuan; Liao; Jo-Nan; Li; Cheng-Hung; Huang; Jin-Long; Hsieh; Yu-Cheng; Wu; Tsu-Juey; Ying-Chieh; Chiang; Hsiao; Hsiang-Chiang; Yeh; Tung-Chen; Wei-Siang; Wen-Yu; Kuo; Jen-Yuan; Hong; Chong-Lie; Yih-Je; Ying-Siang; Tsai; Jui-Peng; Sung; Kuo-Tzu; Sheng-Hsiung
- Ewha Authors
- 박준범
- SCOPUS Author ID
- 박준범
- Issue Date
- 2023
- Journal Title
- Scientific Reports
- ISSN
- 2045-2322
- Citation
- Scientific Reports vol. 13, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia–Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38–0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22–0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences. © 2023, The Author(s).
- DOI
- 10.1038/s41598-023-45345-3
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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