Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이한아 | * |
dc.date.accessioned | 2024-02-15T05:12:03Z | - |
dc.date.available | 2024-02-15T05:12:03Z | - |
dc.date.issued | 2024 | * |
dc.identifier.issn | 0269-2813 | * |
dc.identifier.other | OAK-34653 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267843 | - |
dc.description.abstract | Background: Data on patients switched to tenofovir alafenamide (TAF) from nucleos(t)ide analogues (NUCs) other than tenofovir disoproxil fumarate are limited. Aims: To assess the treatment and renal/bone safety outcomes following the switch to TAF. Methods: We prospectively enrolled adult patients with chronic hepatitis B (CHB) who switched from any NUC to TAF at 14 centres in Japan, Korea, Taiwan and the U.S. Study outcomes were viral suppression (VR; HBV DNA < 20 IU/mL), biochemical response (BR; alanine aminotransferase normalisation), and changes in estimated glomerular filtration rate (eGFR) and T-scores (L-spine) by bone absorptiometry by 24 months after switch to TAF. Results: We enrolled 270 eligible patients. Mean age was 58.1; 58.2% were male; 12.2% had cirrhosis and 73.3% previously received entecavir monotherapy. VR rate increased significantly from 95.2% to 98.8% by 24 months after the switch to TAF (p = 0.014). Between the switch and 24 months later, the mean spine T-score improved significantly from −1.43 ± 1.36 to −1.17 ± 1.38 (p < 0.0001), while there was no significant change in mean eGFR (88.4 ± 16.9–89.5 ± 16.3 mL/min/1.73 m2, p = 0.13). On multivariable analysis adjusted for age, sex, baseline spine T-score and prior TDF or adefovir dipivoxil use, male sex was significantly associated with lower risk of worsening spine T-score (odds ratio: 0.29, p = 0.020), while age was significantly associated with a higher risk of worsening chronic kidney disease stage (OR: 1.07, p = 0.019). Conclusions: At 24 months after the switch to TAF, VR rates and spine bone density improved significantly while renal function remained stable. © 2023 John Wiley & Sons Ltd. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc | * |
dc.subject | bone density | * |
dc.subject | entecavir | * |
dc.subject | hepatitis B virus | * |
dc.subject | sequential therapy | * |
dc.subject | tenofovir alafenamide | * |
dc.title | Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 59 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 239 | * |
dc.relation.lastpage | 248 | * |
dc.relation.journaltitle | Alimentary Pharmacology and Therapeutics | * |
dc.identifier.doi | 10.1111/apt.17785 | * |
dc.identifier.scopusid | 2-s2.0-85174800920 | * |
dc.author.google | Ogawa | * |
dc.author.google | Eiichi | * |
dc.author.google | Jun | * |
dc.author.google | Dae Won | * |
dc.author.google | Toyoda | * |
dc.author.google | Hidenori | * |
dc.author.google | Hsu | * |
dc.author.google | Yao-Chun | * |
dc.author.google | Yoon | * |
dc.author.google | Eileen L. | * |
dc.author.google | Ahn | * |
dc.author.google | Sang Bong | * |
dc.author.google | Yeh | * |
dc.author.google | Ming-Lun | * |
dc.author.google | Do | * |
dc.author.google | Son | * |
dc.author.google | Trinh | * |
dc.author.google | Huy N. | * |
dc.author.google | Takahashi | * |
dc.author.google | Hirokazu | * |
dc.author.google | Enomoto | * |
dc.author.google | Masaru | * |
dc.author.google | Kawada | * |
dc.author.google | Norifumi | * |
dc.author.google | Yasuda | * |
dc.author.google | Satoshi | * |
dc.author.google | Tseng | * |
dc.author.google | Cheng-Hao | * |
dc.author.google | Kawashima | * |
dc.author.google | Keigo | * |
dc.author.google | Lee | * |
dc.author.google | Han Ah | * |
dc.author.google | Inoue | * |
dc.author.google | Kaori | * |
dc.author.google | Haga | * |
dc.author.google | Hiroaki | * |
dc.author.google | Ai-Thien | * |
dc.author.google | Maeda | * |
dc.author.google | Mayumi | * |
dc.author.google | Hoang | * |
dc.author.google | Joseph H. | * |
dc.author.google | Cheung | * |
dc.author.google | Ramsey | * |
dc.author.google | Ueno | * |
dc.author.google | Yoshiyuki | * |
dc.author.google | Eguchi | * |
dc.author.google | Yuichiro | * |
dc.author.google | Furusyo | * |
dc.author.google | Norihiro | * |
dc.author.google | Yu | * |
dc.author.google | Ming-Lung | * |
dc.author.google | Tanaka | * |
dc.author.google | Yasuhito | * |
dc.author.google | Nguyen | * |
dc.author.google | Mindie H. | * |
dc.contributor.scopusid | 이한아(57190980926;5831162710) | * |
dc.date.modifydate | 20240502145036 | * |