Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김휘영 | * |
dc.date.accessioned | 2024-02-15T05:11:54Z | - |
dc.date.available | 2024-02-15T05:11:54Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1572-0241 | * |
dc.identifier.other | OAK-34388 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267799 | - |
dc.description.abstract | INTRODUCTION: Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) for the prevention of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B; however, it has distinct long-term renal and bone toxicities. This study aimed to develop and validate a machine learning model (designated as Prediction of Liver cancer using Artificial intelligence-driven model for Network-antiviral Selection for hepatitis B [PLAN-S]) to predict an individualized risk of HCC during ETV or TDF therapy. METHODS: This multinational study included 13,970 patients with chronic hepatitis B. The derivation (n = 6,790), Korean validation (n = 4,543), and Hong Kong-Taiwan validation cohorts (n = 2,637) were established. Patients were classified as the TDF-superior group when a PLAN-S-predicted HCC risk under ETV treatment is greater than under TDF treatment, and the others were defined as the TDF-nonsuperior group. RESULTS: The PLAN-S model was derived using 8 variables and generated a c-index between 0.67 and 0.78 for each cohort. The TDF-superior group included a higher proportion of male patients and patients with cirrhosis than the TDF-nonsuperior group. In the derivation, Korean validation, and Hong Kong-Taiwan validation cohorts, 65.3%, 63.5%, and 76.4% of patients were classified as the TDF-superior group, respectively. In the TDF-superior group of each cohort, TDF was associated with a significantly lower risk of HCC than ETV (hazard ratio = 0.60-0.73, all P < 0.05). In the TDF-nonsuperior group, however, there was no significant difference between the 2 drugs (hazard ratio = 1.16-1.29, all P > 0.1). DISCUSSION: Considering the individual HCC risk predicted by PLAN-S and the potential TDF-related toxicities, TDF and ETV treatment may be recommended for the TDF-superior and TDF-nonsuperior groups, respectively. Copyright © 2023 by The American College of Gastroenterology. | * |
dc.language | English | * |
dc.title | Personalized Antiviral Drug Selection in Patients With Chronic Hepatitis B Using a Machine Learning Model: A Multinational Study | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 118 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1963 | * |
dc.relation.lastpage | 1972 | * |
dc.relation.journaltitle | The American journal of gastroenterology | * |
dc.identifier.doi | 10.14309/ajg.0000000000002234 | * |
dc.identifier.wosid | WOS:001102204200013 | * |
dc.identifier.scopusid | 2-s2.0-85161405227 | * |
dc.author.google | Hur | * |
dc.author.google | Moon Haeng | * |
dc.author.google | Park | * |
dc.author.google | Min Kyung | * |
dc.author.google | Yip | * |
dc.author.google | Terry Cheuk-Fung | * |
dc.author.google | Chen | * |
dc.author.google | Chien-Hung | * |
dc.author.google | Lee | * |
dc.author.google | Hyung-Chul | * |
dc.author.google | Choi | * |
dc.author.google | Won-Mook | * |
dc.author.google | Kim | * |
dc.author.google | Seung Up | * |
dc.author.google | Lim | * |
dc.author.google | Young-Suk | * |
dc.author.google | Soo Young | * |
dc.author.google | Wong | * |
dc.author.google | Grace Lai-Hung | * |
dc.author.google | Sinn | * |
dc.author.google | Dong Hyun | * |
dc.author.google | Jin | * |
dc.author.google | Young-Joo | * |
dc.author.google | Sung Eun | * |
dc.author.google | Peng | * |
dc.author.google | Cheng-Yuan | * |
dc.author.google | Shin | * |
dc.author.google | Hyun Phil | * |
dc.author.google | Chi-Yi | * |
dc.author.google | Hwi Young | * |
dc.author.google | Han Ah | * |
dc.author.google | Seo | * |
dc.author.google | Yeon Seok | * |
dc.author.google | Jun | * |
dc.author.google | Dae Won | * |
dc.author.google | Yoon | * |
dc.author.google | Eileen L. | * |
dc.author.google | Sohn | * |
dc.author.google | Joo Hyun | * |
dc.author.google | Ahn | * |
dc.author.google | Sang Bong | * |
dc.author.google | Shim | * |
dc.author.google | Jae-Jun | * |
dc.author.google | Jeong | * |
dc.author.google | Soung Won | * |
dc.author.google | Cho | * |
dc.author.google | Yong Kyun | * |
dc.author.google | Hyoung Su | * |
dc.author.google | Jang | * |
dc.author.google | Myoung-Jin | * |
dc.author.google | Yoon Jun | * |
dc.author.google | Jung-Hwan | * |
dc.author.google | Jeong-Hoon | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.date.modifydate | 20240601081000 | * |