Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이진화 | * |
dc.contributor.author | 김남은 | * |
dc.date.accessioned | 2024-02-15T05:11:48Z | - |
dc.date.available | 2024-02-15T05:11:48Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2077-0383 | * |
dc.identifier.other | OAK-34341 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267771 | - |
dc.description.abstract | COPD is a heterogeneous disease, and its acute exacerbation is a major prognostic factor. We used cluster analysis to predict COPD exacerbation due to subtypes of mild–moderate airflow limitation. In all, 924 patients from the Korea COPD Subgroup Study cohort, with a forced expiratory volume (FEV1) ≥ 50% and documented age, body mass index (BMI), smoking status, smoking pack-years, COPD assessment test (CAT) score, predicted post-bronchodilator FEV1, were enrolled. Four groups, putative chronic bronchitis (n = 224), emphysema (n = 235), young smokers (n = 248), and near normal (n = 217), were identified. The chronic bronchitis group had the highest BMI, and the one with emphysema had the oldest age, lowest BMI, and highest smoking pack-years. The young smokers group had the youngest age and the highest proportion of current smokers. The near-normal group had the highest proportion of never-smokers and near-normal lung function. When compared with the near-normal group, the emphysema group had a higher risk of acute exacerbation (OR: 1.93, 95% CI: 1.29–2.88). However, multiple logistic regression showed that chronic bronchitis (OR: 2.887, 95% CI: 1.065–8.192), predicted functional residual capacity (OR: 1.023, 95% CI: 1.007–1.040), fibrinogen (OR: 1.004, 95% CI: 1.001–1.008), and gastroesophageal reflux disease were independent predictors of exacerbation (OR: 2.646, 95% CI: 1.142–6.181). The exacerbation-susceptible subtypes require more aggressive prevention strategies. © 2023 by the authors. | * |
dc.language | English | * |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | * |
dc.subject | acute exacerbation | * |
dc.subject | k-means clustering | * |
dc.subject | multicenter observation cohort study | * |
dc.subject | subtypes of COPD | * |
dc.title | Subtypes of Patients with Mild to Moderate Airflow Limitation as Predictors of Chronic Obstructive Pulmonary Disease Exacerbation | * |
dc.type | Article | * |
dc.relation.issue | 20 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Journal of Clinical Medicine | * |
dc.identifier.doi | 10.3390/jcm12206643 | * |
dc.identifier.wosid | WOS:001093544600001 | * |
dc.identifier.scopusid | 2-s2.0-85175155521 | * |
dc.author.google | Kim | * |
dc.author.google | Nam Eun | * |
dc.author.google | Kang | * |
dc.author.google | Eun-Hwa | * |
dc.author.google | Jung | * |
dc.author.google | Ji Ye | * |
dc.author.google | Lee | * |
dc.author.google | Chang Youl | * |
dc.author.google | Won Yeon | * |
dc.author.google | Lim | * |
dc.author.google | Seong Yong | * |
dc.author.google | Park | * |
dc.author.google | Dong Il | * |
dc.author.google | Yoo | * |
dc.author.google | Kwang Ha | * |
dc.author.google | Ki-Suck | * |
dc.author.google | Jin Hwa | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.contributor.scopusid | 김남은(57222473513;57207987214) | * |
dc.date.modifydate | 20240419140935 | * |