Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경진 | * |
dc.date.accessioned | 2024-02-15T05:11:47Z | - |
dc.date.available | 2024-02-15T05:11:47Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-34334 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267765 | - |
dc.description.abstract | Global longitudinal strain (GLS) is a valuable indicator of subclinical myocardial dysfunction. Whether the effect of aging on subclinical left ventricular dysfunction is sex-specific is not well documented. This study aimed to identify age-related changes in GLS according to sex in patients with a normal left ventricular ejection fraction (LVEF). In this cross-sectional, single-center cohort study in Korea, participants who underwent GLS measurement using 2D speckle-tracking echocardiography were retrospectively reviewed, and participants with normal LVEF (≥ 55%) without documented cardiovascular disease were included. Reduced GLS was defined as absolute values below 18%. Of 682 study participants (mean age, 58; female, 51.5%), 209 (30.6%) had reduced GLS. Females with reduced GLS were older than those with normal GLS (68 vs. 58 years, P < 0.001); with no difference of age in males (55 vs. 57 years; P = 0.265). Univariate analysis showed age to correlate significantly with reduced GLS only in female (r = − 0.364; P < 0.001). In multivariable analysis, female > 66 years old had significantly higher risk of reduced GLS (Odds ratio 2.66; 95% CI 1.22–5.76; P = 0.014). In participants with normal LVEF, GLS decreased with age in females but not in males. Particularly, females aged 66 years and older had a significantly higher risk of reduced GLS. These findings suggest that GLS could be a valuable parameter for assessing subclinical cardiac dysfunction, especially in older females. © 2023, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | Sex difference in the age-related decline of global longitudinal strain of left ventricle | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-023-42286-9 | * |
dc.identifier.wosid | WOS:001092348300062 | * |
dc.identifier.scopusid | 2-s2.0-85174943891 | * |
dc.author.google | Lee | * |
dc.author.google | Kyung-Yeon | * |
dc.author.google | Kim | * |
dc.author.google | Hack-Lyoung | * |
dc.author.google | Kyung-Jin | * |
dc.contributor.scopusid | 김경진(57190021870) | * |
dc.date.modifydate | 20240426120924 | * |