Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정혜경 | - |
dc.date.accessioned | 2024-02-15T05:11:46Z | - |
dc.date.available | 2024-02-15T05:11:46Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.other | OAK-34329 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267761 | - |
dc.description.abstract | Background/Aims It remains unclear which maintenance treatment modality is most appropriate for mild gastroesophageal reflux disease (GERD). We aimed to compare on-demand treatment with continuous treatment using a proton pump inhibitor (PPI) in the maintenance treatment for patients with non-erosive GERD or mild erosive esophagitis. Methods Patients whose GERD symptoms improved after 4 weeks of standard dose PPI treatment were prospectively enrolled at 25 hospitals. Subsequently, the enrolled patients were randomly assigned to either an on-demand or a continuous maintenance treatment group, and followed in an 8-week interval for up to 24 weeks. Results A total of 304 patients were randomized to maintenance treatment (continuous, n = 151 vs on-demand, n = 153). The primary outcome, the overall proportion of unwillingness to continue the assigned maintenance treatment modality, failed to confirm the non-inferiority of on-demand treatment (45.9%) compared to continuous treatment (36.1%). Compared with the on-demand group, the GERD symptom and health-related quality of life scores significantly more improved and the overall satisfaction score was significantly higher in the continuous treatment group, particularly at week 8 and week 16 of maintenance treatment. Work impairment scores were not different in the 2 groups, but the prescription cost was less in the on-demand group. Serum gastrin levels significantly elevated in the continuous treatment group, but not in the on-demand group. Conclusions Continuous treatment seems to be more appropriate for the initial maintenance treatment of non-erosive GERD or mild erosive esophagitis than on-demand treatment. Stepping down to on-demand treatment needs to be considered after a sufficient period of continuous treatment. © 2023 The Korean Society of Neurogastroenterology and Motility. | - |
dc.language | English | - |
dc.publisher | Korean Society of Neurogastroenterology and Motility | - |
dc.subject | Gastroesophageal reflux | - |
dc.subject | Maintenance | - |
dc.subject | Proton pump inhibitors | - |
dc.title | On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 29 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 460 | - |
dc.relation.lastpage | 469 | - |
dc.relation.journaltitle | Journal of Neurogastroenterology and Motility | - |
dc.identifier.doi | 10.5056/jnm23130 | - |
dc.identifier.wosid | WOS:001091833800001 | - |
dc.identifier.scopusid | 2-s2.0-85174961627 | - |
dc.author.google | Jung | - |
dc.author.google | Da Hyun | - |
dc.author.google | Youn | - |
dc.author.google | Young Hoon | - |
dc.author.google | Hye-Kyung | - |
dc.author.google | Kim | - |
dc.author.google | Seung Young | - |
dc.author.google | Huh | - |
dc.author.google | Cheal Wung | - |
dc.author.google | Shin | - |
dc.author.google | Cheol Min | - |
dc.author.google | Oh | - |
dc.author.google | Jung-Hwan | - |
dc.author.google | Kyu Chan | - |
dc.author.google | Park | - |
dc.author.google | Moo In | - |
dc.author.google | Choi | - |
dc.author.google | Suck Chei | - |
dc.author.google | Ki Bae | - |
dc.author.google | Seon-Young | - |
dc.author.google | Kwon | - |
dc.author.google | Joong Goo | - |
dc.author.google | Cho | - |
dc.author.google | Yu Kyung | - |
dc.author.google | Jung Ho | - |
dc.author.google | Jeong Eun | - |
dc.author.google | Gong | - |
dc.author.google | Eun Jeong | - |
dc.author.google | Jae Hak | - |
dc.author.google | Hong | - |
dc.author.google | Su Jin | - |
dc.author.google | Hyun Jin | - |
dc.author.google | Jee | - |
dc.author.google | Sam Ryong | - |
dc.author.google | Lee | - |
dc.author.google | Ju Yup | - |
dc.author.google | Kee Wook | - |
dc.author.google | Hee Man | - |
dc.author.google | Kwang Jae | - |
dc.contributor.scopusid | 정혜경(7403029723) | - |
dc.date.modifydate | 20240208151845 | - |