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Association between changes in predicted body composition and occurrence of heart failure: a nationwide population study
- Title
- Association between changes in predicted body composition and occurrence of heart failure: a nationwide population study
- Authors
- Woo, Ho Geol; Kim, Dong-Hyeok; Lee, Hyungwoo; Kang, Min Kyoung; Song, Tae-Jin
- Ewha Authors
- 송태진; 김동혁; 강민경; 이형우
- SCOPUS Author ID
- 송태진; 김동혁; 강민경; 이형우
- Issue Date
- 2023
- Journal Title
- FRONTIERS IN ENDOCRINOLOGY
- ISSN
- 1664-2392
- Citation
- FRONTIERS IN ENDOCRINOLOGY vol. 14
- Keywords
- body composition; body mass index; obesity; skeletal mass; fat mass; heart failure
- Publisher
- FRONTIERS MEDIA SA
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Large population-based studies on the association between changes in body composition and the occurrence of heart failure (HF) are rare. We aimed to determine the association between changes in body composition, including the predicted body fat mass index (pBFMI), predicted appendicular skeletal muscle mass index (pASMI), and predicted lean body mass index (pLBMI), and the occurrence of HF. Methods: For present study, 2,036,940 people who consecutively underwent national health examinations from 2010 similar to 2011 (baseline period) to 2012 similar to 2013 (follow-up period) were included. The pBFMI, pASMI, and pLBMI were indirectly investigated using validated anthropometric prediction equations from the Korean National Health and Nutrition Examination Survey cohort. The outcome was defined as at least two or more claims of HF. Results: During a median of 7.59 years of follow-up, 22,172 participants (event rate, 1.09%) with HF were observed. Decreased changes in the pASMI and pLBMI were associated with the occurrence of HF among males (hazard ratio [HR] 0.966, 95% confidence interval (CI) [0.944-0.988]; HR 0.939, 95%CI [0.923-0.955], respectively) and females (HR 0.924, 95%CI [0.900-0.947]; HR 0.951, 95%CI [0.939-0.963], respectively). An increased change in the pBFMI was associated with the occurrence of HF in males (HR 1.017, 95%CI [1.001-1.034]). However, paradoxically, a change in the pBFMI was associated with the occurrence of HF in females (HR 0.925, 95%CI [0.909-0.942]). Conclusion: Decreased skeletal muscle mass was related to the occurrence of HF. However, the relationship between a change in fat mass and the occurrence of HF was different and even paradoxical depending on sex.
- DOI
- 10.3389/fendo.2023.1210371
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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