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Association between Pneumonia Development and Virulence Gene Expression in Carbapenem-Resistant <i>Acinetobacter baumannii</i> Isolated from Clinical Specimens
- Title
- Association between Pneumonia Development and Virulence Gene Expression in Carbapenem-Resistant <i>Acinetobacter baumannii</i> Isolated from Clinical Specimens
- Authors
- Bae, Ji Yun; Yun, Ina; Jun, Kang Il; Kim, Chung-Jong; Lee, Miae; Choi, Hee Jung
- Ewha Authors
- 이미애; 최희정; 김충종; 배지윤; 전강일
- SCOPUS Author ID
- 이미애; 최희정; 김충종; 배지윤; 전강일
- Issue Date
- 2023
- Journal Title
- CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
- ISSN
- 1712-9532
1918-1493
- Citation
- CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY vol. 2023
- Publisher
- HINDAWI LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We investigated the virulence gene expression of carbapenem-resistant Acinetobacter baumanii (CRAB) isolated from the respiratory samples of patients with CRAB pneumonia and those with CRAB colonization to identify the virulence genes contributing to CRAB pneumonia's development and mortality. Patients with CRAB identified from respiratory specimens were screened at a tertiary university hospital between January 2018 and January 2019. Patients were classified into CRAB pneumonia or CRAB colonization groups according to predefined clinical criteria. A. baumannii isolated from respiratory specimens was examined for the expression levels of ompA, uspA, hfq, hisF, feoA, and bfnL by quantitative reverse-transcription polymerase chain reaction. Among 156 patients with CRAB from respiratory specimens, 17 and 24 met the criteria for inclusion in the pneumonia and colonization groups, respectively. The expression level of ompA was significantly higher in the pneumonia group than in the colonization group (1.45 vs. 0.63, P=0.03). The expression levels of ompA (1.97 vs. 0.86, P = 0.02), hisF (1.06 vs. 0.10, P < 0.01), uspA (1.62 vs. 1.01, P < 0.01), and bfnL (3.14 vs. 2.14, P=0.03) were significantly higher in patients with 30-day mortality than in the surviving patients. Elevated expression of hisF (adjusted odds ratio = 5.93, P=0.03) and uspA (adjusted odds ratio = 7.36, P=0.02) were associated with 30-day mortality after adjusting for age and the Charlson score. uspA and hisF may serve as putative targets for novel therapeutic strategies.
- DOI
- 10.1155/2023/8265683
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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