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Clinical Benefit of Intravascular Imaging Compared with Conventional Angiography in Left Main Coronary Artery Intervention
- Title
- Clinical Benefit of Intravascular Imaging Compared with Conventional Angiography in Left Main Coronary Artery Intervention
- Authors
- Kwon; Woochan; Lee; Joo Myung; Yun; Kyeong Ho; Choi; Ki Hong; Seung-Jae; Jong-Young; Sang Yeub; Kim; Sang Min; Cho; Jae Young; Chan Joon; Ahn; Hyo-Suk; Nam; Chang-Wook; Yoon; Hyuck-Jun; Park; Yong Hwan; Wang Soo; Jeong; Jin-Ok; Song; Pil Sang; Doh; Joon-Hyung; Jo; Sang-Ho; Chang-Hwan; Kang; Min Gyu; Koh; Jin-Sin; Kwan Yong; Lim; Young-Hyo; Yun-Hyeong; Jin-Man; Jang; Woo Jin; Chun; Kook-Jin; Hong; David; Taek Kyu; Yang; Jeong Hoon; Seung-Hyuk; Gwon; Hyeon-Cheol; Hahn; Joo-Yong; Young Bin
- Ewha Authors
- 장우진
- SCOPUS Author ID
- 장우진
- Issue Date
- 2023
- Journal Title
- Circulation: Cardiovascular Interventions
- ISSN
- 1941-7640
- Citation
- Circulation: Cardiovascular Interventions vol. 16, no. 12, pp. E013359
- Keywords
- angiography; coronary artery; patients; percutaneous coronary intervention; prognosis
- Publisher
- Lippincott Williams and Wilkins
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- BACKGROUND: The RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance Versus Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) demonstrated that intravascular imaging-guided percutaneous coronary intervention (PCI) improved clinical outcome compared with angiography-guided PCI for patients with complex coronary artery lesions. This study aims to assess whether the prognostic benefit of intravascular imaging-guided procedural optimization persists in patients undergoing PCI for left main coronary artery disease. METHODS: Of 1639 patients enrolled in the RENOVATE-COMPLEX-PCI, 192 patients with left main coronary artery disease were selected for the current prespecified substudy. Selected patients were randomly assigned to either the intravascular imaging-guided PCI group (n=138) or the angiography-guided PCI group (n=54). The primary end point was target vessel failure defined as a composite of cardiac death, target vessel-related myocardial infarction, or clinically driven target vessel revascularization. RESULTS: At a median follow-up of 2.1 years (interquartile range 1.1 to 3.0 years), intravascular imaging-guided PCI was associated with lower incidence of primary end point compared with angiography-guided PCI (6.8% versus 25.1%; hazard ratio, 0.31 [95% CI, 0.13-0.76]; P=0.010). This significant reduction in primary end point was mainly driven by a lower risk of cardiac death or spontaneous target vessel-related myocardial infarction (1.6% versus 12.7%; hazard ratio, 0.16 [95% CI, 0.03-0.82]; P=0.028). Intravascular imaging-guided PCI was independently associated with a lower risk of primary end point, even after adjusting for various clinical factors (hazard ratio, 0.29 [95% CI, 0.12-0.72]; P=0.007). CONCLUSIONS: Intravascular imaging-guided PCI showed clinical benefit over angiography-guided PCI for left main coronary artery disease in reducing the risk of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03381872. © 2023 Lippincott Williams and Wilkins. All rights reserved.
- DOI
- 10.1161/CIRCINTERVENTIONS.123.013359
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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