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Factors associated with failure of cardiopulmonary function recovery after lung cancer surgery
- Title
- Factors associated with failure of cardiopulmonary function recovery after lung cancer surgery
- Authors
- Kong; Sunga; Shin; Sumin; Jeon; Yeong Jeong; Lee; Genehee; Cho; Jong Ho; Kim; Hong Kwan; Shim; Young Mog; Juhee; Kang; Danbee; Park; Hye Yun
- Ewha Authors
- 신수민
- SCOPUS Author ID
- 신수민
- Issue Date
- 2023
- Journal Title
- Respirology
- ISSN
- 1323-7799
- Citation
- Respirology vol. 28, no. 11, pp. 1060 - 1068
- Keywords
- cardiopulmonary function; lung cancer; patients reported outcomes; physical activity; pulmonary function; surgery
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and Objective: This study aimed to evaluate the longitudinal changes in cardiopulmonary function (CPF) and identify predictors of cardiopulmonary recovery failure after lung cancer surgery. Methods: Data was obtained from a prospective CATCH-LUNG cohort study, where patients were divided into two groups based on 6-min walk distance (6MWD) at baseline and 6 months after surgery. CPF recovery failure was defined as a participant whose 6MWD dropped over 50 m from baseline to 6 months after surgery. Patients with a baseline 6MWD less than 400 m were excluded. The analysis was investigated using mixed effects models, and the relative estimates for the predictors were expressed relative risk (RR) and 95% CI using a Poisson regression. Results: Among 419 patients, 24.1% and 17.7% showed failure of CPF recovery at 6 months and 1 year after surgery, respectively. In the multivariable analysis, baseline step count [RR per 1000 steps lower = 1.05 (95% CI, 1.01–1.09)], baseline dyspnoea [RR per 10 points higher = 1.15(1.07–1.23)], decreased FEV1% predicted from baseline to 2 weeks after surgery [RR per 10% lower = 1.30(1.10–1.53)] and decreased moderate-to-vigorous physical activity (MVPA) from baseline to 2 weeks [RR = 1.95(1.22, 3.11)] or persistent low MVPA at baseline and 2 weeks after surgery [RR = 1.63(1.04, 2.54)] were significant factors for loss of CPF. Conclusion: The inability to recover CPF at 6 months after surgery was linked to reduction of lung function and MVPA from baseline to 2 weeks as well as baseline physical activity (PA) and dyspnoea. These results imply that engagement of perioperative PA is necessary to facilitate recovery of CPF after lung cancer surgery. © 2023 Asian Pacific Society of Respirology.
- DOI
- 10.1111/resp.14581
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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