View : 156 Download: 0
Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study
- Title
- Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study
- Authors
- Jo; Eun-Jung; Lee; Ji-Hyang; Won; Ha-Kyeong; Kang; Noeul; Sung-Yoon; Seung Eun; Ji-Ho; Kim; Mi-Yeong; Shim; Ji-Su; An; Jin; Yoo; Youngsang; Park; So-Young; Byung-Keun; Moon; Ji-Yong; Han-Ki; Min-Hye; Kwon; Hyouk-Soo; Sae-Hoon; Sang-Heon; Chang; Yoon-Seok; Sang-Hoon; Birring; Surinder S.; Byung-Jae; Song; Woo-Jung
- Ewha Authors
- 김민혜; 심지수
- SCOPUS Author ID
- 김민혜; 심지수
- Issue Date
- 2023
- Journal Title
- Lung
- ISSN
- 0341-2040
- Citation
- Lung vol. 201, no. 5, pp. 477 - 488
- Keywords
- Cough; Patient outcome assessment; Prospective studies; Registries
- Publisher
- Springer
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline cohort profile and study protocols. Methods: This multicenter, prospective observational cohort study included newly referred CC patients and those already being treated for refractory or unexplained chronic cough (RUCC). Cough status was assessed using a visual analog scale, the Leicester Cough Questionnaire (LCQ), and the Cough Hypersensitivity Questionnaire (CHQ). Results: A total of 610 patients (66.9% women; median age 59.0 years) were recruited from 18 centers, with 176 being RUCC patients (28.9%). The median age at CC onset was 50.1 years, and 94.4% had adult-onset CC (≥ 19 years). The median cough duration was 4 years. Compared to newly referred CC patients, RUCC patients had a longer cough duration (6.0 years vs. 3.0 years) but had fewer symptoms and signs suggesting asthma, rhinosinusitis, or gastroesophageal acid reflux disease. Subjects with RUCC had lower LCQ scores (10.3 ± 3.3 vs. 11.6 ± 3.6; P < 0.001) and higher CHQ scores (9.1 ± 3.9 vs. 8.4 ± 4.1; P = 0.024). There were no marked differences in the characteristics of cough between refractory chronic cough and unexplained chronic cough. Conclusions: Chronic cough typically develops in adulthood, lasting for years. Cough severity and quality of life impairment indicate the presence of unmet clinical needs and insufficient cough control in real-world clinical practice. Longitudinal follow-up is warranted to investigate the natural history and treatment outcomes. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- DOI
- 10.1007/s00408-023-00644-4
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML