Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안정훈 | * |
dc.contributor.author | 김충종 | * |
dc.date.accessioned | 2024-02-01T16:30:50Z | - |
dc.date.available | 2024-02-01T16:30:50Z | - |
dc.date.issued | 2024 | * |
dc.identifier.issn | 0195-6701 | * |
dc.identifier.other | OAK-34778 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266934 | - |
dc.description.abstract | Background: Despite the significant impact of multi-drug-resistant bacteraemia, especially extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) and carbapenem-resistant Enterobacterales (CRE), the burden of disease has not been investigated thoroughly. Aim: To evaluate the clinical outcomes and socio-economic burden of ESBL-E and CRE bacteraemia nationwide in the Republic of Korea. Methods: A search was undertaken for all cases of ESBL-E and CRE bacteraemia and matched controls in 10 hospitals in the Republic of Korea over 6 months. Patients with ESBL-E or CRE bacteraemia were classified as the R group, and matched controls with antibiotic-susceptible bacteraemia and without infection were classified as the S and N groups, respectively. Patients' clinical data were collected, and the economic burden was estimated based on medical expenses, loss of productivity and total costs. Findings: In total, 795 patients were identified, including 265 patients with ESBL-E or CRE bacteraemia and their matched controls. The mean total length of stay for patients with ESBL-E and CRE in the R group was 1.53 and 1.90 times that of patients in the S group, respectively. The 90-day mortality rates for ESBL-E in the R and S groups were 12.1% and 5.6%, respectively, and the corresponding figures for CRE were 28.6% and 12.0%. There were significant differences in the total costs between the R, S and N groups for both ESBL-E and CRE (ESBL-E: $11,151 vs $8712 vs $6063, P=0.004; CRE: $40,464 vs $8748 vs $7279, P=0.024). Conclusion: The clinical and economic burden imposed by ESBL-E or CRE bacteraemia was extremely high. These findings suggest that efforts to control resistant bacteraemia are necessary to reduce this burden. © 2023 The Authors | * |
dc.language | English | * |
dc.publisher | W.B. Saunders Ltd | * |
dc.subject | Bacteraemia | * |
dc.subject | Carbapenem-resistant Enterobacterales | * |
dc.subject | Economic burden | * |
dc.subject | Extended-spectrum beta-lactamase | * |
dc.subject | Mortality | * |
dc.title | Disease burden of bacteraemia with extended-spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales in Korea | * |
dc.type | Article | * |
dc.relation.volume | 144 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 85 | * |
dc.relation.lastpage | 93 | * |
dc.relation.journaltitle | Journal of Hospital Infection | * |
dc.identifier.doi | 10.1016/j.jhin.2023.11.013 | * |
dc.identifier.wosid | WOS:001164345300001 | * |
dc.identifier.scopusid | 2-s2.0-85182373525 | * |
dc.author.google | Lee | * |
dc.author.google | C.M. | * |
dc.author.google | S. | * |
dc.author.google | Kim | * |
dc.author.google | E.S. | * |
dc.author.google | H.B. | * |
dc.author.google | Park | * |
dc.author.google | W.B. | * |
dc.author.google | Moon | * |
dc.author.google | S.M. | * |
dc.author.google | Y.K. | * |
dc.author.google | K-H. | * |
dc.author.google | Kwak | * |
dc.author.google | Y.G. | * |
dc.author.google | B. | * |
dc.author.google | Y.S. | * |
dc.author.google | C-J. | * |
dc.author.google | Gil | * |
dc.author.google | H-Y. | * |
dc.author.google | Ahn | * |
dc.author.google | J. | * |
dc.author.google | Song | * |
dc.contributor.scopusid | 안정훈(8855402200) | * |
dc.contributor.scopusid | 김충종(45361165100) | * |
dc.date.modifydate | 20240527135444 | * |