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Changes in smoking status, amount of smoking and their relation to the risk of microvascular complications in men with diabetes mellitus
- Title
- Changes in smoking status, amount of smoking and their relation to the risk of microvascular complications in men with diabetes mellitus
- Authors
- Park, Sung Keun; Kim, Min-Ho; Jung, Ju Young; Oh, Chang-Mo; Ha, Eunhee; Nam, Do Jin; Yang, Eun Hye; Hwang, Woo Yeon; Lee, Sangho; Ryoo, Jae-Hong
- Ewha Authors
- 하은희
- SCOPUS Author ID
- 하은희
- Issue Date
- 2023
- Journal Title
- DIABETES-METABOLISM RESEARCH AND REVIEWS
- ISSN
- 1520-7552
1520-7560
- Citation
- DIABETES-METABOLISM RESEARCH AND REVIEWS vol. 39, no. 8
- Keywords
- diabetes mellitus; microvascular complications; nephropathy; retinopathy and neuropathy; smoking
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Smoking is a definite risk factor for macrovascular complications in diabetes mellitus (DM). However, the effect of smoking on microvascular complications is inconclusive. Method: Study participants were 26,673 diabetic men who received health checkup both in 2003-2004 and 2009, excluding women. Assessing smoking status (never, quitting and current) at 2003-2004 and 2009, changes in smoking status were categorised into 7 groups (nevernever, never-quitting, never-current, quitting-quitting, quitting-current, current-quitting and current-current). Smoking amount was categorised into never, light (0-10 pack years), moderate (10-20 pack years), and heavy smoking (>20 pack years) based on 2009 data. They were followed-up until 2013 to identify incident microvascular complications. We calculated the adjusted hazard ratios (HR) and 95% confidence interval (CI) (adjusted HR [95% CI]) for incident microvascular complications according to changes in smoking status and smoking amount. Results: Current-quitting (1.271 [1.050-1.538]), current-current (1.243 [1.070-1.444]) and heavy smoking (1.238 [1.078-1.422]) were associated with an increased risk of overall microvascular complications. The risk of nephropathy increased in current-current smoking (1.429 [1.098-1.860]) and heavy smoking (1.357 [1.061-1.734]). An increased risk of neuropathy was observed in current-quitting smoking (1.360 [1.076-1.719]), current-current smoking (1.237 [1.025-1.492]) and heavy smoking (1.246 [1.048-1.481]). However, we couldn't see the interpretable findings for the association between smoking and retinopathy. Conclusions: Lasting and heavy smoking increases the risk of microvascular complications, including nephropathy and neuropathy. Quitting smoking and reducing smoking amount are imperative in preventing microvascular complications in DM patients.
- DOI
- 10.1002/dmrr.3697|http://dx.doi.org/10.1002/dmrr.3697
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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