Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김휘영 | * |
dc.contributor.author | 이한아 | * |
dc.date.accessioned | 2023-10-19T16:31:15Z | - |
dc.date.available | 2023-10-19T16:31:15Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2589-0042 | * |
dc.identifier.other | OAK-34141 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266275 | - |
dc.description.abstract | Transmembrane 4 L six family member 5 (TM4SF5) engages in non-alcoholic steatohepatitis (NASH), although its mechanistic roles are unclear. Genetically engineered Tm4sf5 mice fed ad libitum normal chow or high-fat diet for either an entire day or a daytime-feeding (DF) pattern were analyzed for metabolic parameters. Compared to wild-type and Tm4sf5(-/-) knockout mice, hepatocyte-specific TM4SF5-overexpressing Alb-TG(Tm4sf5-Flag) (TG) mice showed abnormal food-intake behavior during the mouse-inactive daytime, increased apelin expression, increased food intake, and higher levels of NASH features. DF or exogenous apelin injection of TG mice caused severe hepatic pathology. TM4SF5-mediated abnormal food intake was correlated with peroxisomal beta-oxidation, mTOR activation, and autophagy inhibition, with triggering NASH phenotypes. Non-alcoholic fatty liver disease (NAFLD) patients' samples revealed a correlation between serum apelin and NAFLD activity score. Altogether, these observations suggest that hepatic TM4SF5 may cause abnormal food-intake behaviors to trigger steatohepatitic features via the regulation of peroxisomal beta-oxidation, mTOR, and autophagy. | * |
dc.language | English | * |
dc.publisher | CELL PRESS | * |
dc.title | TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 26 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | ISCIENCE | * |
dc.identifier.doi | 10.1016/j.isci.2023.107625 | * |
dc.identifier.wosid | WOS:001091180500001 | * |
dc.identifier.scopusid | 2-s2.0-85168714874 | * |
dc.author.google | Pinanga, Yangie Dwi | * |
dc.author.google | Lee, Han Ah | * |
dc.author.google | Shin, Eun-Ae | * |
dc.author.google | Lee, Haesong | * |
dc.author.google | Pyo, Kyung-hee | * |
dc.author.google | Kim, Ji Eon | * |
dc.author.google | Lee, Eun Hae | * |
dc.author.google | Kim, Wonsik | * |
dc.author.google | Kim, Soyeon | * |
dc.author.google | Kim, Hwi Young | * |
dc.author.google | Weon, Jung | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.contributor.scopusid | 이한아(57190980926;5831162710) | * |
dc.date.modifydate | 20240429140130 | * |