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Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation
- Title
- Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation
- Authors
- Sur, Bongjun; Kim, Mijin; Villa, Thea; Oh, Seikwan
- Ewha Authors
- 오세관; 서봉준
- SCOPUS Author ID
- 오세관; 서봉준
- Issue Date
- 2023
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- ISSN
- 1976-9148
2005-4483
- Citation
- BIOMOLECULES & THERAPEUTICS vol. 31, no. 5, pp. 536 - 543
- Keywords
- Arthritis; Phytoceramide; TNF-a; Anti-inflammatory; Fibroblast-like synoviocytes
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis rat model and fibroblast-like synoviocytes (FLS). Pcer treatment (1, 10, and 30 mg/kg/day) were given to the arthritic rats for 6 days after disease induction. Weight distribution ration (WDR), knee thickness, squeaking score, serum levels of proinflammatory mediators, and histological analysis were measured and performed to evaluate arthritic symptoms in the rat model. In interleukin (IL)-1 beta-stimulated FLS, proinflammatory mediators were measured after Pcer (1-30 mu M) treatment. Arthritic symptoms in rats with Pcer treatment were significantly decreased at days 4 to 6 after C/K arthritis induction. Inflammation in the knee joints were also significantly decreased in rats with Pcer treatment. Furthermore, in IL-1 beta-stimulated FLS, the expressions of proinflammatory mediators were also inhibited by Pcer. As shown by the results, Pcer has anti-arthritic effects in the C/K rat model and in synovial cells, suggesting that Pcer has the potential to be a useful agent in arthritis treatment.
- DOI
- 10.4062/biomolther.2023.031
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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