NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
의과대학
의학과
Journal papers
View : 152 Download: 61
Accurate Detection of Urothelial Bladder Cancer Using Targeted Deep Sequencing of Urine DNA
Title
Accurate Detection of Urothelial Bladder Cancer Using Targeted Deep Sequencing of Urine DNA
Authors
Lee D.
;
Lee W.
;
Kim H.-P.
;
Kim M.
;
Ahn H.K.
;
Bang D.
;
Kim K.H.
Ewha Authors
김광현
;
김명
;
안현규
SCOPUS Author ID
김광현
; 김명
; 안현규
Issue Date
2023
Journal Title
Cancers
ISSN
2072-6694
Citation
Cancers vol. 15, no. 10
Keywords
bladder cancer
;
early cancer detection
;
non-invasive cancer detection
;
target deep sequencing
;
urine tumor DNA
Publisher
MDPI
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Patients with hematuria are commonly given an invasive cystoscopy test to detect bladder cancer (BC). To avoid the risks associated with cystoscopy, several urine-based methods for BC detection have been developed, the most prominent of which is the deep sequencing of urine DNA. However, the current methods for urine-based BC detection have significant levels of false-positive signals. In this study, we report on uAL100, a method to precisely detect BC tumor DNA in the urine without tumor samples. Using urine samples from 43 patients with BC and 21 healthy donors, uAL100 detected BC with 83.7% sensitivity and 100% specificity. The mutations identified in the urine DNA by uAL100 for BC detection were highly associated with BC tumorigenesis and progression. We suggest that uAL100 has improved accuracy compared to other urine-based methods for early BC detection and can reduce unnecessary cystoscopy tests for patients with hematuria. © 2023 by the authors.
DOI
10.3390/cancers15102868
Appears in Collections:
의과대학
>
의학과
>
Journal papers
Files in This Item:
cancers-15-02868.pdf
(3.12 MB)
Download
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject