Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김지은 | * |
dc.date.accessioned | 2023-04-14T16:31:19Z | - |
dc.date.available | 2023-04-14T16:31:19Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 0340-5354 | * |
dc.identifier.other | OAK-33081 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264923 | - |
dc.description.abstract | Background: We aimed to evaluate the diagnostic accuracy of enzyme-linked immunosorbent assay (ELISA) for anti-muscle specific tyrosine kinase (MuSK) antibody (Ab) in a large cohort of anti-acetylcholine receptor (AChR) Ab-negative generalized myasthenia gravis (MG), and also to investigate clinical contexts for the diagnosis of MuSK MG. Methods: A retrospective study of 160 patients with a clinical suspicion of AChR Ab-negative generalized MG was performed. The serum samples were tested for anti-clustered AChR Ab by cell-based assay (CBA), anti-MuSK Ab by ELISA, CBA and/or radioimmunoprecipitation assay (RIPA). Clinical data were compared between anti-MuSK Ab-positive MG and double seronegative (AChR and MuSK) MG groups. Results: After excluding non-MG and clustered AChR Ab-positive patients, we identified 89 patients as a cohort of AChR Ab-negative generalized MG. Anti-MuSK Ab was positive by ELISA in 22 (24.7%) patients. While CBA identified five additional anti-MuSK Ab-positive patients, the results of ELISA were mostly consistent with CBA and RIPA with Cohen’s kappa of 0.80 and 0.90, respectively (p < 0.001). The most frequent differential diagnosis was motor neuron disease particularly of bulbar onset which showed remarkably overlapping clinical and electrophysiological features with MuSK MG at presentation. Conclusion: While confirming the highest sensitivity of CBA for detecting anti-MuSK Ab, our results highlight the clinical pitfalls in making a diagnosis of MuSK MG and may support a diagnostic utility of MuSK-ELISA in clinical practice. © 2022, The Author(s). | * |
dc.language | English | * |
dc.publisher | Springer Science and Business Media Deutschland GmbH | * |
dc.subject | Anti-MuSK antibody | * |
dc.subject | Cell-based assay | * |
dc.subject | ELISA | * |
dc.subject | Radioimmunoprecipitation assay | * |
dc.subject | Seronegative myasthenia gravis | * |
dc.title | Clinical pitfalls and serological diagnostics of MuSK myasthenia gravis | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 270 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1478 | * |
dc.relation.lastpage | 1486 | * |
dc.relation.journaltitle | Journal of Neurology | * |
dc.identifier.doi | 10.1007/s00415-022-11458-4 | * |
dc.identifier.scopusid | 2-s2.0-85142151342 | * |
dc.author.google | Kwon Y.N. | * |
dc.author.google | Woodhall M. | * |
dc.author.google | Sung J.-J. | * |
dc.author.google | Kim K.-K. | * |
dc.author.google | Lim Y.-M. | * |
dc.author.google | Kim H. | * |
dc.author.google | Kim J.-E. | * |
dc.author.google | Baek S.-H. | * |
dc.author.google | Kim B.-J. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Seok H.Y. | * |
dc.author.google | Kim D.-S. | * |
dc.author.google | Kwon O. | * |
dc.author.google | Park K.H. | * |
dc.author.google | Sohn E. | * |
dc.author.google | Bae J.S. | * |
dc.author.google | Yoon B.-N. | * |
dc.author.google | Kim N.-H. | * |
dc.author.google | Ahn S.-W. | * |
dc.author.google | Choi K. | * |
dc.author.google | Oh J. | * |
dc.author.google | Park H.J. | * |
dc.author.google | Shin K.J. | * |
dc.author.google | Lee S. | * |
dc.author.google | Park J. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Seok J.I. | * |
dc.author.google | Bae D.W. | * |
dc.author.google | An J.Y. | * |
dc.author.google | Joo I.S. | * |
dc.author.google | Choi S.-J. | * |
dc.author.google | Nam T.-S. | * |
dc.author.google | Kim S. | * |
dc.author.google | Park K.-J. | * |
dc.author.google | Kwon K.-H. | * |
dc.author.google | Waters P. | * |
dc.author.google | Hong Y.-H. | * |
dc.contributor.scopusid | 김지은(36663634500) | * |
dc.date.modifydate | 20240318130340 | * |