Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최윤희 | * |
dc.contributor.author | 김원중 | * |
dc.contributor.author | 오혜원 | * |
dc.contributor.author | 이현정 | * |
dc.contributor.author | 채지선 | * |
dc.date.accessioned | 2023-04-14T16:31:08Z | - |
dc.date.available | 2023-04-14T16:31:08Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1999-4923 | * |
dc.identifier.other | OAK-33163 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264846 | - |
dc.description.abstract | Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NF kappa B) is thought to play an important role in the mechanism of CRPS. Recently, exosomes loaded with super-repressor inhibitory kappa B (Exo-srI kappa B, I kappa B; inhibitor of NF kappa B) have been shown to have potential anti-inflammatory effects in various inflammatory disease models. We investigated the therapeutic effect of Exo-srI kappa B on a rodent model with chronic post-ischemia pain (CPIP), a representative animal model of Type I CRPS. After intraperitoneal injection of a vehicle, Exo-srI kappa B, and pregabalin, the paw withdrawal threshold (PWT) was evaluated up to 48 h. Administration of Exo-srI kappa B increased PWT compared to the vehicle and pregabalin, and the relative densities of p-I kappa B and I kappa B showed significant changes compared to the vehicle 24 h after Exo-srI kappa B injection. The levels of several cytokines and chemokines were reduced by the administration of Exo-srI kappa B in mice with CPIP. In conclusion, our results showed more specifically the role of NF kappa B in the pathogenesis of CRPS and provided a theoretical background for novel treatment options for CRPS. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | exosomes | * |
dc.subject | exosome loaded with super-repressor I kappa B | * |
dc.subject | chronic post-ischemic pain model | * |
dc.subject | complex regional pain syndrome (CRPS) | * |
dc.subject | allodynia | * |
dc.subject | NF kappa B | * |
dc.subject | inflammation | * |
dc.subject | neuropathic pain | * |
dc.title | The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srI kappa Bs) in Chronic Post-Ischemia Pain (CPIP) Models | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PHARMACEUTICS | * |
dc.identifier.doi | 10.3390/pharmaceutics15020553 | * |
dc.identifier.wosid | WOS:000941655600001 | * |
dc.identifier.scopusid | 2-s2.0-85149147645 | * |
dc.author.google | Chae, Ji Seon | * |
dc.author.google | Park, Hyunju | * |
dc.author.google | Ahn, So-Hee | * |
dc.author.google | Han, Eun-Chong | * |
dc.author.google | Lee, Yoonjin | * |
dc.author.google | Kim, Youn Jin | * |
dc.author.google | Ahn, Eun-Jin | * |
dc.author.google | Oh, Hye-Won | * |
dc.author.google | Lee, Hyun Jung | * |
dc.author.google | Choi, Chulhee | * |
dc.author.google | Choi, Youn-Hee | * |
dc.author.google | Kim, Won-joong | * |
dc.contributor.scopusid | 최윤희(7404776849) | * |
dc.contributor.scopusid | 김원중(55492115800) | * |
dc.contributor.scopusid | 오혜원(57223011616) | * |
dc.contributor.scopusid | 이현정(57216716580) | * |
dc.contributor.scopusid | 채지선(57201666939) | * |
dc.date.modifydate | 20240429142116 | * |