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Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
- Title
- Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
- Authors
- Song, Seung Hwan; Chung, Ku Yong; Jee, Yongho; Chung, Hae-Sun; Kim, Kina; Minn, Dohsik; Kim, Soo-Kyung
- Ewha Authors
- 정혜선; 송승환; 김수경
- SCOPUS Author ID
- 정혜선; 송승환; 김수경
- Issue Date
- 2023
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- ISSN
- 1011-8934
1598-6357
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE vol. 38, no. 5
- Keywords
- COVID-19; Kidney Transplantation; SARS-CoV-2; Vaccine
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (>= 100 U/mL) and neutralizing antibody responses (>= 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1-2.4, 2.5-4.9, and >= 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7-52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine. A shorter time from transplantation to vaccination was a risk factor for a low antibody response.
- DOI
- 10.3346/jkms.2023.38.e22
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.pdf(1.41 MB)
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