Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오세영 | * |
dc.date.accessioned | 2023-02-22T16:30:25Z | - |
dc.date.available | 2023-02-22T16:30:25Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1422-0067 | * |
dc.identifier.other | OAK-33049 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/263968 | - |
dc.description.abstract | Alzheimer's disease (AD) is the most common neurodegenerative disease and the blood-brain barrier dysfunction has been suggested as a key pathological feature of the disease. Our research group successfully established a synthetic protocol for oleracones, a novel series of flavonoids isolated from the plant extract of Portulaca oleracea L. (PO). PO extract was reported to have anti-inflammatory and antioxidant effects, enhancing cognitive function. Thus, we investigated the effects and mechanism of oleracones on cognition using AD model transgenic mice (Tg; APPswe/PSEN1dE9). Oleracone F treatment significantly improved memory dysfunction in Tg mice. Oleracone F decreased the number, burden, and immunoreactivity of amyloid plaques and amyloid precursor protein (APP) protein levels in the brains of Tg mice compared to wild-type mice. Oleracone F also alleviated inflammation observed in Tg mice brains. In vitro studies in human microvascular endothelial cells (HBMVECs) demonstrated that oleracones D, E, and F blocked the elevations in VCAM-1 protein induced by tumor necrosis factor-alpha (TNF-alpha), hindering leukocyte adhesion to HBMVECs. Taken together, our results suggest that oleracones ameliorated cognitive impairment by blocking TNF-alpha-induced increases in VCAM-1, thereby reducing leukocyte infiltration to the brain and modulating brain inflammation. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | oleracone | * |
dc.subject | vascular cell adhesion molecule-1 | * |
dc.subject | tumor necrosis factor-alpha | * |
dc.subject | Alzheimer's disease | * |
dc.subject | blood-brain barrier | * |
dc.title | Oleracone F Alleviates Cognitive Impairment and Neuropathology in APPswe/PSEN1dE9 Mice by Reducing the Expression of Vascular Cell Adhesion Molecule and Leukocyte Adhesion to Brain Vascular Endothelial Cells | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | * |
dc.identifier.doi | 10.3390/ijms24032056 | * |
dc.identifier.wosid | WOS:000930470000001 | * |
dc.identifier.scopusid | 2-s2.0-85147894479 | * |
dc.author.google | Kwon, Young-Sun | * |
dc.author.google | Ko, Jin-Sung | * |
dc.author.google | Oh, Se-Young | * |
dc.author.google | Han, Young Taek | * |
dc.author.google | Jo, Sangmee Ahn | * |
dc.contributor.scopusid | 오세영(57275601000) | * |
dc.date.modifydate | 20240222153905 | * |