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JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
- Title
- JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
- Authors
- Lee, Gilyoung; Ahn, Huijeong; Yun, Jang-Hyuk; Park, Jeongho; Lee, Eunsong; Oh, Seikwan; Lee, Geun-Shik
- Ewha Authors
- 오세관
- SCOPUS Author ID
- 오세관
- Issue Date
- 2022
- Journal Title
- SCIENTIFIC REPORTS
- ISSN
- 2045-2322
- Citation
- SCIENTIFIC REPORTS vol. 12, no. 1
- Publisher
- NATURE PORTFOLIO
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Dysregulation of inflammasome activation induces chronic and excess inflammation resulting in several disorders, such as metabolic disorders and cancers. Thus, screening for its regulator derived from natural materials has been conducted progressively. JC2-11 (JC) was designed to enhance the antioxidant activity based on a chalcone, which is abundant in edible plants and a precursor of flavonoids. This study examined the effects of JC on inflammasome activation in human and murine macrophages. JC inhibited the secretion of interleukin (IL)-1 beta and lactate dehydrogenases, and the cleavage of caspase-1 and gasdermin D in response to the tested activators (i.e., NLRP3, NLRC4, AIM2, and non-canonical inflammasome triggers). In addition, JC attenuated IL-1 beta secretion from lipopolysaccharide (LPS)-injected mice, an inflammasome-mediating disease model. Mechanistically, JC blocked the expression of the inflammasome components during the priming step of the inflammasome, and interrupted the production of mitochondrial reactive oxygen species. In addition, JC inhibited the activity of caspase-1. In conclusion, JC may be a candidate pan-inflammasome inhibitor.
- DOI
- 10.1038/s41598-022-27129-3
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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