Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이진화 | * |
dc.date.accessioned | 2023-01-18T16:32:47Z | - |
dc.date.available | 2023-01-18T16:32:47Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2077-0383 | * |
dc.identifier.other | OAK-32888 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/263821 | - |
dc.description.abstract | We evaluated whether the pathogens identified during acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) are associated with the COPD medications used in the 6 months before AE-COPD. We collected the medical records of patients diagnosed with AE-COPD at 28 hospitals between January 2008 and December 2019 and retrospectively analyzed them. Microorganisms identified at the time of AE-COPD were analyzed according to the use of inhaled corticosteroid (ICS) and systemic steroid after adjusting for COPD severity. We evaluated 1177 patients with AE-COPD and available medication history. The mean age of the patients was 73.9 +/- 9.2 years, and 83% were males. The most frequently identified bacteria during AE-COPD were Pseudomonas aeruginosa (10%), followed by Mycoplasma pneumoniae (9.4%), and Streptococcus pneumoniae (5.1%), whereas the most commonly identified viruses were rhinovirus (11%) and influenza A (11%). During AE-COPD, bacteria were more frequently identified in the ICS than non-ICS group (p = 0.009), and in the systemic steroid than non-systemic steroid group (p < 0.001). In patients who used systemic steroids before AE-COPD, the risk of detecting Pseudomonas aeruginosa was significantly higher during AE-COPD (OR 1.619, CI 1.007-2.603, p = 0.047), but ICS use did not increase the risk of Pseudomonas detection. The risk of respiratory syncytial virus (RSV) detection was low when ICS was used (OR 0.492, CI 0.244-0.988, p = 0.045). COPD patients who used ICS had a lower rate of RSV infection and similar rate of P. aeruginosa infection during AE-COPD compared to patients who did not use ICS. However, COPD patients who used systemic steroids within 6 months before AE-COPD had an increased risk of P. aeruginosa infection. Therefore, anti-pseudomonal antibiotics should be considered in patients with AE-COPD who have used systemic steroids. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | respiratory pathogen | * |
dc.subject | chronic obstructive pulmonary disease | * |
dc.subject | inhaler | * |
dc.title | COPD Exacerbation-Related Pathogens and Previous COPD Treatment | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | JOURNAL OF CLINICAL MEDICINE | * |
dc.identifier.doi | 10.3390/jcm12010111 | * |
dc.identifier.wosid | WOS:000908834900001 | * |
dc.identifier.scopusid | 2-s2.0-85145921916 | * |
dc.author.google | Sim, Yun Su | * |
dc.author.google | Lee, Jin Hwa | * |
dc.author.google | Lee, Eung Gu | * |
dc.author.google | Choi, Joon Young | * |
dc.author.google | Lee, Chang-Hoon | * |
dc.author.google | An, Tai Joon | * |
dc.author.google | Park, Yeonhee | * |
dc.author.google | Yoon, Young Soon | * |
dc.author.google | Park, Joo Hun | * |
dc.author.google | Yoo, Kwang Ha | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.date.modifydate | 20240419140935 | * |