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Accelerated Partial Breast Irradiation Florence Phase 3 Trial Experience and Future Perspectives
- Title
- Accelerated Partial Breast Irradiation Florence Phase 3 Trial Experience and Future Perspectives
- Authors
- Meattini, Icro; Kim, Kyubo; Livi, Lorenzo
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2023
- Journal Title
- AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- ISSN
- 0277-3732
1537-453X
- Citation
- AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS vol. 46, no. 1, pp. 10 - 15
- Keywords
- partial breast irradiation; intensity-modulated radiotherapy; breast cancer; Florence trial; phase 3
- Publisher
- LIPPINCOTT WILLIAMS &
WILKINS
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Accelerated partial breast irradiation Florence phase 3 trial is a single-center study comparing intensity-modulated based accelerated partial breast irradiation (PBI, 30 Gy in 5 fractions) and whole breast irradiation (50 Gy in 25 fractions) followed by a tumor bed boost (10 Gy in 5 fractions). This easy-to-deliver PBI approach showed excellent long-term disease control with favorable safety and cosmetic outcome profiles. A plateau has been probably reached concerning the reduction of the number of fractions in the postoperative PBI setting. A 5-fraction schedule is the standard regimen and probably the appropriate compromise in terms of efficacy, safety, and quality of life, also considering the negative results of most intraoperative single-fraction PBI trials. A new frontier is now open on the potential benefit of preoperative PBI delivery, although concerns remain on the optimal dose, fractionation, and technique. Hereby we report the accelerated PBI Florence phase 3 trial experience and future perspectives.
- DOI
- 10.1097/COC.0000000000000968
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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