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Accuracy of the New Creatinine-based Equations for Estimating Glomerular Filtration Rate in Koreans
- Title
- Accuracy of the New Creatinine-based Equations for Estimating Glomerular Filtration Rate in Koreans
- Authors
- Jeong, Tae-Dong; Hong, Jinyoung; Lee, Woochang; Chun, Sail; Min, Won-Ki
- Ewha Authors
- 정태동
- SCOPUS Author ID
- 정태동
- Issue Date
- 2023
- Journal Title
- ANNALS OF LABORATORY MEDICINE
- ISSN
- 2234-3806
2234-3814
- Citation
- ANNALS OF LABORATORY MEDICINE vol. 43, no. 3, pp. 244 - 252
- Keywords
- Accuracy; Estimated glomerular filtration rate; Creatinine
- Publisher
- KOREAN SOC LABORATORY MEDICINE
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background: New creatinine-based estimated glomerular filtration rate (eGFR) equations, including the 2021 Chronic Kidney Disease Epidemiology Collaboration (2021 CKD-EPI) and European Kidney Function Consortium (EKFC) equations, have been introduced re-cently. We assessed the performance of the 2021 CKD-EPI and EKFC equations in the Korean population.Methods: We analyzed 1,654 Korean patients aged >= 18 years who underwent chromium-51-ethylenediamine tetraacetic acid GFR measurements (mGFR). Bias (eGFR-mGFR), root mean square error (RMSE), and proportion of eGFR within 30% of mGFR (P30) of the 2009 CKD-EPI, 2021 CKD-EPI, and EFKC equations were compared. The concor-dance rate between eGFR and mGFR categories was evaluated. Both eGFR and mGFR categories were classified into six groups: >= 90, 89-60, 59-45, 44-30, 29-15, and <15 mL/min/1.73 m2.Results: The median bias (mL/min/1.73 m2) was 1.8 for the 2009 CKD-EPI equation, 4.8 for the 2021 CKD-EPI equation, and -0.3 for the EKFC equation. The P30 and RMSE were 78.2% and 17.0 for the 2009 CKD-EPI equation, 75.6% and 17.4 for the 2021 CKD-EPI equation, and 80.0% and 16.7 for the EKFC equation, respectively. The overall GFR cate-gory concordance rate between eGFR and mGFR was 63.4% for the 2009 CKD-EPI equa-tion, 60.5% for the 2021 CKD-EPI equation, and 61.0% for the EKFC equation.Conclusions: Among the three eGFR equations, the EKFC equation had the smallest bias and highest P30 in Koreans. The 2009 CKD-EPI equation had a lower bias than the 2021 CKD-EPI equation.
- DOI
- 10.3343/alm.2023.43.3.244|http://dx.doi.org/10.3343/alm.2023.43.3.244
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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