Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 최윤희 | * |
dc.contributor.author | 안정혁 | * |
dc.contributor.author | 신정아 | * |
dc.contributor.author | 박현주 | * |
dc.contributor.author | 임지우 | * |
dc.date.accessioned | 2023-01-06T16:30:07Z | - |
dc.date.available | 2023-01-06T16:30:07Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.issn | 0219-1032 | * |
dc.identifier.other | OAK-32803 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/263065 | - |
dc.description.abstract | Aging is a major risk factor for common neurodegenerative diseases. Although multiple molecular, cellular, structural, and functional changes occur in the brain during aging, the involvement of caveolin-2 (Cav-2) in brain ageing remains unknown. We investigated Cav-2 expression in brains of aged mice and its effects on endothelial cells. The human umbilical vein endothelial cells (HUVECs) showed decreased THP-1 adhesion and infiltration when treated with Cav-2 siRNA compared to control siRNA. In contrast, Cav-2 overexpression increased THP-1 adhesion and infiltration in HUVECs. Increased expression of Cav-2 and iba-1 was observed in brains of old mice. Moreover, there were fewer iba-1-positive cells in the brains of aged Cav-2 knockout (KO) mice than of wild-type aged mice. The levels of several chemokines were higher in brains of aged wild-type mice than in young wild -type mice; moreover, chemokine levels were significantly lower in brains of young mice as well as aged Cav-2 KO mice than in their wild-type counterparts. Expression of PECAM1 and VE-cadherin proteins increased in brains of old wild -type mice but was barely detected in brains of young wild -type and Cav-2 KO mice. Collectively, our results suggest that Cav-2 expression increases in the endothelial cells of aged brain, and promotes leukocyte infiltration and age-associated neuroinflammation. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC MOLECULAR & | * |
dc.publisher | CELLULAR BIOLOGY | * |
dc.subject | aging | * |
dc.subject | cav2- | * |
dc.subject | - mouse | * |
dc.subject | caveolin-2 | * |
dc.subject | endothelial cell | * |
dc.subject | neuroinflammation | * |
dc.title | Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 950 | * |
dc.relation.lastpage | 962 | * |
dc.relation.journaltitle | MOLECULES AND CELLS | * |
dc.identifier.doi | 10.14348/molcells.2022.0045 | * |
dc.identifier.wosid | WOS:000921241100005 | * |
dc.identifier.scopusid | 2-s2.0-85144638479 | * |
dc.author.google | Park, Hyunju | * |
dc.author.google | Shin, Jung A. | * |
dc.author.google | Lim, Jiwoo | * |
dc.author.google | Lee, Seulgi | * |
dc.author.google | Ahn, Jung-Hyuck | * |
dc.author.google | Kang, Jihee Lee | * |
dc.author.google | Choi, Youn-Hee | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 최윤희(7404776849) | * |
dc.contributor.scopusid | 안정혁(35081632000) | * |
dc.contributor.scopusid | 신정아(56559179800) | * |
dc.contributor.scopusid | 박현주(55821533400) | * |
dc.contributor.scopusid | 임지우(58029000200) | * |
dc.date.modifydate | 20240429132222 | * |