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Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study
- Title
- Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study
- Authors
- Moon, So Young; Kim, Sohui; Choi, Seong Hye; Hong, Chang Hyung; Park, Yoo Kyoung; Na, Hae Ri; Song, Hong-Sun; Park, Hee Kyung; Choi, Muncheong; Lee, Sun Min; Chun, Buong-O; Lee, Jong-Min; Jeong, Jee Hyang
- Ewha Authors
- 정지향; 박희경
- SCOPUS Author ID
- 정지향; 박희경
- Issue Date
- 2022
- Journal Title
- NEUROTHERAPEUTICS
- ISSN
- 1933-7213
1878-7479
- Citation
- NEUROTHERAPEUTICS vol. 19, no. 5, pp. 1514 - 1525
- Keywords
- Cortical thickness; Dementia; Prevention; Lifestyle; Intervention
- Publisher
- SPRINGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on cortical thickness, brain volume, and the serum brain-derived neurotrophic factor (BDNF). Totally, 152 participants, aged 60-79 years without dementia but with >= 1 modifiable dementia risk factor, were randomly assigned to the FMI, HMI, or control groups. Among them, 55 participants (20 FMI, 19 HMI, and 16 controls) underwent brain MRI at baseline and 24 weeks. We compared changes in global/regional mean cortical thickness at the region-of-interest (ROI) between the intervention and control groups. The changes in the total cortical gray matter volume and global mean cortical thickness were compared using analysis of covariance with age, sex, and education as covariates. ComBat site harmonization was applied for cortical thickness values across the scanners. ROI-based analysis was controlled for multiple comparisons, with a false discovery rate threshold of p < 0.05. Serum BDNF levels were significantly higher in the FMI group than in the control group (p = 0.029). Compared with the control group, the mean global cortical thickness increased in the FMI group (0.033 +/- 0.070 vs. - 0.003 +/- 0.040, p = 0.013); particularly, cortical thickness of the bilateral frontotemporal lobes, cingulate gyri, and insula increased. The increase in cortical thickness and serum BDNF in the FMI group suggests that group preventive strategies at the facility may be beneficial through structural neuroplastic changes in brain areas, which facilitates learning and neurotrophic factors.
- DOI
- 10.1007/s13311-022-01276-x
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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