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Associations of neuralgic amyotrophy with COVID-19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database
- Title
- Associations of neuralgic amyotrophy with COVID-19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database
- Authors
- Kim J.-E.; Park J.; Min Y.G.; Hong Y.-H.; Song T.-J.
- Ewha Authors
- 송태진; 박진; 김지은
- SCOPUS Author ID
- 송태진; 박진; 김지은
- Issue Date
- 2022
- Journal Title
- Muscle and Nerve
- ISSN
- 0148-639X
- Citation
- Muscle and Nerve vol. 66, no. 6, pp. 766 - 770
- Keywords
- COVID-19; neuralgic amyotrophy; Parsonage-Turner syndrome; SARS-CoV-2; vaccination
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Introduction/Aims: There are limited studies on the association of COVID-19 vaccination with neuralgic amyotrophy (NA). Therefore, we evaluated the association between COVID-19 vaccination and the occurrence of NA. Methods: We explored unexpected safety signals for NA related to COVID-19 vaccination through disproportionality analysis using VigiBase, the World Health Organization's pharmacovigilance database. Results: On October 15, 2021, 335 cases of NA were identified in the database. The median time to onset of NA after vaccination was around 2 weeks. A significant signal of disproportionality of NA was observed for the ChAdOx1 nCoV-19 vaccine (AstraZeneca) (information component [IC]025 = 0.33, reporting odds ratio [ROR]025 = 1.30) and two mRNA-based COVID-19 vaccines (BNT162b2 [Pfizer and BioNTech] and mRNA-1273 [Moderna]) (IC025 = 1.74, ROR025 = 3.82) compared with the entire database. However, when compared with influenza vaccines, we did not detect any signal of disproportionality of NA for both the ChAdOx1 nCoV-19 vaccine (IC025 = −2.71, ROR025 = 0.05) and mRNA-based COVID-19 vaccines (IC025 = −1.38, ROR025 = 0.13). Discussion: A weak association was observed between NA and COVID-19 vaccines. However, the risk did not surpass that of influenza vaccines. © 2022 Wiley Periodicals LLC.
- DOI
- 10.1002/mus.27734
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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