Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민석 | * |
dc.date.accessioned | 2023-01-04T16:31:09Z | - |
dc.date.available | 2023-01-04T16:31:09Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1754-1611 | * |
dc.identifier.other | OAK-32596 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262990 | - |
dc.description.abstract | Chronic myeloid leukemia is generally required bone marrow biopsy for diagnosis. Although examining peripheral blood is less invasive, it has not been fully validated as a routine diagnostic test due to suboptimal sensitivity. To overcome this limitation, a number of methodologies based on microfluidics have been developed for sorting circulating tumor cells from peripheral blood of patients with leukemia. In order to develop a more convenient method, we designed an analysis protocol using motion microscopy that amplifies cellular micro motions in a captured video by re-rendering pixels to generate extreme magnified visuals. Intriguingly, no fluctuations around leukemic myeloblasts were observed with a motion microscope at any wavelength of 0–10 Hz. However, use of 0.05% hyaluronic acid, one type of non-newtonian fluid, demonstrated fluctuations around leukemic myeloblasts under conditions of 25 μm/s and 0.5–1.5 Hz with a motion microscope. Thus, the non-invasive detection of leukemic myeloblasts can offer a valuable supplementary diagnostic tool for assessment of drug efficacy for monitoring patients with chronic myeloid leukemia. © 2022, The Author(s). | * |
dc.language | English | * |
dc.publisher | BioMed Central Ltd | * |
dc.subject | Microfluidic system | * |
dc.subject | Motion microscopy | * |
dc.subject | Myeloid leukemia | * |
dc.subject | Vibration | * |
dc.title | Label-free detection of leukemic myeloblasts in hyaluronic acid | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Journal of Biological Engineering | * |
dc.identifier.doi | 10.1186/s13036-022-00308-6 | * |
dc.identifier.wosid | WOS:000877690600001 | * |
dc.identifier.scopusid | 2-s2.0-85141046820 | * |
dc.author.google | Park S. | * |
dc.author.google | Kim H. | * |
dc.author.google | Woo M. | * |
dc.author.google | Kim M. | * |
dc.contributor.scopusid | 김민석(55686393700) | * |
dc.date.modifydate | 20240222124201 | * |