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Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry
- Title
- Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry
- Authors
- Jeon, Hoyeon; Lim, Younghyun; Lee, In-Gu; Kim, Dong-In; Kim, Keun Pil; Hong, So-Hee; Kim, Jeongkyu; Jung, Youn-Sang; Seo, Young-Jin
- Ewha Authors
- 홍소희
- SCOPUS Author ID
- 홍소희
- Issue Date
- 2022
- Journal Title
- JOURNAL OF MICROBIOLOGY
- ISSN
- 1225-8873
1976-3794
- Citation
- JOURNAL OF MICROBIOLOGY vol. 60, no. 11, pp. 1113 - 1121
- Keywords
- influenza A virus; KIF20A; paprotrain
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- The influenza A virus (IAV) has caused several pandemics, and therefore there are many ongoing efforts to identify novel antiviral therapeutic strategies including vaccines and antiviral drugs. However, influenza viruses continuously undergo antigenic drift and shift, resulting in the emergence of mutated viruses. In turn, this decreases the efficiency of existing vaccines and antiviral drugs to control IAV infection. Therefore, this study sought to identify alternative therapeutic strategies targeting host cell factors rather than viruses to avoid infection by mutated viruses. Particularly, we investigated the role of KIF20A that is one of kinesin superfamily proteins in the replication of IAV. The KIF20A increased viral protein levels in IAV-infected cells by regulating the initial entry stage during viral infection. Furthermore, the KIF20A inhibitor significantly suppressed viral replication, which protected mice from morbidity and mortality. Therefore, our findings demonstrated that KIF20A is highly involved in the viral replication process and viral propagation both in vitro and in vivo, and could thus be used as a target for the development of novel antiviral drugs.
- DOI
- 10.1007/s12275-022-2436-x
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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