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Evaluation of the Efficacy of COVID-19 Booster Vaccinations in Healthcare Personnel
- Title
- Evaluation of the Efficacy of COVID-19 Booster Vaccinations in Healthcare Personnel
- Authors
- Kim, Chung-Jong; Bae, Ji-Yun; Jun, Kang-Il; Kim, Jihee; Son, Hee-Jung; Chung, Hae-Sun; Kim, Soo-Kyung; Kim, Soohyun; Minn, Dohsik; Choi, Hee-Jung
- Ewha Authors
- 최희정; 정혜선; 김충종; 배지윤; 김수경; 전강일
- SCOPUS Author ID
- 최희정; 정혜선; 김충종; 배지윤; 김수경; 전강일
- Issue Date
- 2022
- Journal Title
- VACCINES
- ISSN
- 2076-393X
- Citation
- VACCINES vol. 10, no. 11
- Keywords
- COVID-19 vaccines; COVID-19 vaccine booster shot; antibodies; SARS-CoV-2
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This study aimed to investigate the efficacy of different COVID-19 booster vaccines by measuring the serum antibody titer. SARS-CoV-2 anti-nucleocapsid protein antibody (N-Ab), anti-spike protein antibody (S-Ab), and neutralizing antibody (Neut.Ab) were measured before and 4-6 weeks after booster vaccinations in healthcare personnel with a previous vaccination within 3-6 months. Personnel who previously received two doses of ChAdOx1 vaccine or two doses of BNT162b2 vaccine received the BNT162b2 vaccine (AAP and PPP groups, respectively). Personnel who previously received two doses of mRNA-1273 received the same vaccine as a booster dose (MMM group). Of the 917 participants, the AAP, MMM, and PPP groups comprised 837 (91.3%), 27 (2.9%), and 53 (5.8%) participants, respectively. The pre-booster S-Ab and Neut.Ab titer were significantly lower in the AAP group. After the booster vaccination, all participants were positive for S-Ab and Neut.Ab; furthermore, the S-Ab and Neut.Ab titer significantly increased in all three groups, although the post-booster S-Ab was lower in the AAP group than in the other groups. The post-booster Neut.Ab titer showed no significant difference among the groups. Our study's results suggest that booster vaccination, after two prior vaccinations, shows a significant effect regardless of the type of vaccine administered.
- DOI
- 10.3390/vaccines10111797
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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vaccines-10-01797.pdf(1.6 MB)
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