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Multiple primary cancers in men with sporadic or familial prostate cancer: Its clinical implications
- Title
- Multiple primary cancers in men with sporadic or familial prostate cancer: Its clinical implications
- Authors
- Kim, Myong; Sung, Joohon; Kim, Jung Kwon; Lee, Hakmin; Oh, Jong Jin; Lee, Sangchul; Hong, Sung Kyu; Byun, Seok-Soo
- Ewha Authors
- 김명
- SCOPUS Author ID
- 김명
- Issue Date
- 2022
- Journal Title
- UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- ISSN
- 1078-1439
1873-2496
- Citation
- UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS vol. 40, no. 11
- Keywords
- Prostate cancer; Familial; Multiple primary cancer; Clinical characteristics
- Publisher
- ELSEVIER SCIENCE INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: To evaluate the risk of concordant cancers in patients with prostate cancer (CaP) and examine whether this risk differed according to family history of CaP. Materials and methods: We examined 1,102 patients with CaP , having prospectively acquired pedigrees, and analyzed information regarding multiple primary cancers. The prevalence of concordant cancers was assessed with respect to the family history of CaP . First -degree familial CaP was defined as a positive history of CaP in first-degree relatives (parents, siblings, and offspring). Odds ratios for each concordant cancer in men with first-degree familial CaP were estimated. Clinical characteristics were compared between men with and without concordant cancers. Results: The prevalence of multiple primary cancers in sporadic PCa was 12.0%, similar to that of first-degree familial CaP (13.5%, P = 0.698). Gastrointestinal cancer was the most common concordant cancer (3.6%), followed by colorectal (2.9%), lung (1.5%), urothelial (1.3%), kidney (1.1%), and other cancers. Colorectal cancer was more frequent in first-degree familial CaP than in sporadic disease (6.8 vs. 2.7%, P = 0.045). However, the rates of other concordant cancers were similar between the 2 groups (P range, 0.242-0.963). Compared with sporadic disease, the age-adjusted odds ratio for concordant colorectal cancer in first-degree familial CaP was 2.930 (95% confidence interval, 1.082-7.929). Patients with concordant colorectal cancer had fewer (2.8 vs. 3.9 cores, P = 0.041) and a lower percentage of (23.5 vs. 33.1%, P = 0.030) positive biopsy cores than CaP only patients. Conclusions: A family history of CaP was significantly associated with a risk of concordant colorectal cancer. These findings imply that some CaP shares a genetic pathogenesis with colorectal cancer. (c) 2022 Published by Elsevier Inc.
- DOI
- 10.1016/j.urolonc.2022.07.016
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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