Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤영 | * |
dc.date.accessioned | 2022-11-03T16:30:57Z | - |
dc.date.available | 2022-11-03T16:30:57Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-32524 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262830 | - |
dc.description.abstract | There have been limited studies on the association between prognosis and body weight change in patients with idiopathic pulmonary fibrosis (IPF). This single-center retrospective observational study evaluated the impact of weight loss on outcomes in Korean patients with IPF receiving pirfenidone at a tertiary medical institution. We analyzed 215 IPF patients prescribed pirfenidone from January 1st, 2015 to December 31st, 2019. The patients were categorized into maintained weight (MW; weight gain or loss < 5%/year) and reduced weight (RW; weight loss ≥ 5%/year) groups. The mean age was 71.8 years and 175 (81.4%) were male. There were 54 (25.1%) patients in the RW group. All patients showed a decrease in body weight (baseline vs. after 1 year; 64.1 kg vs. 62.8 kg, P < 0.001). Although baseline lung function showed a difference, there was no difference in the rate of change (forced vital capacity [% of predicted]; P = 0.221, diffusing capacity of the lung for carbon monoxide [% of predicted]; P = 0.973). The MW group had a lower risk of all-cause mortality (P < 0.001). Weight loss appeared to be a significant risk factor for mortality in patients with IPF. Not only disease control with antifibrotic agents, but also efforts to prevent weight loss may be necessary. © 2022, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | Impact of body weight change on clinical outcomes in patients with idiopathic pulmonary fibrosis receiving pirfenidone | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-022-22449-w | * |
dc.identifier.wosid | WOS:000869405100024 | * |
dc.identifier.scopusid | 2-s2.0-85140006488 | * |
dc.author.google | Kim T.H. | * |
dc.author.google | Shin Y.-Y. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Song M.J. | * |
dc.author.google | Kim Y.W. | * |
dc.author.google | Lim S.Y. | * |
dc.author.google | Lee Y.J. | * |
dc.author.google | Park J.S. | * |
dc.author.google | Cho Y.-J. | * |
dc.author.google | Lee J.H. | * |
dc.author.google | Lee C.-T. | * |
dc.author.google | Kwon B.S. | * |
dc.contributor.scopusid | 신윤영(57931193600) | * |
dc.date.modifydate | 20240422140753 | * |