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The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)
- Title
- The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)
- Authors
- Kim, Jae Sik; Kim, Kyubo; Jung, Wonguen; Shin, Kyung Hwan; Im, Seock-Ah; Kim, Hee-Jun; Kim, Yong Bae; Chang, Jee Suk; Kim, Jee Hyun; Choi, Doo Ho; Park, Yeon Hee; Kim, Dae Yong; Kim, Tae Hyun; Choi, Byung Ock; Lee, Sea-Won; Kim, Suzy; Kwon, Jeanny; Kang, Ki Mun; Chung, Woong-Ki; Kim, Kyung Su; Nam, Ji Ho; Yoon, Won Sup; Kim, Jin Hee; Cha, Jihye; Oh, Yoon Kyeong; Kim, In Ah
- Ewha Authors
- 김규보; 정원근
- SCOPUS Author ID
- 김규보; 정원근
- Issue Date
- 2022
- Journal Title
- CANCER RESEARCH AND TREATMENT
- ISSN
- 1598-2998
2005-9256
- Citation
- CANCER RESEARCH AND TREATMENT vol. 54, no. 4, pp. 1121 - 1129
- Keywords
- Brain metastasis; Breast neoplasms; Overall survival; Pattern of care study
- Publisher
- KOREAN CANCER ASSOCIATION
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea. Materials and Methods We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed (group I [2005-2008], 98 patients; group II [2009-2011], 200 patients; and group III [2012-2014], 302 patients). Results Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years; p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p=0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance. Conclusion The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.
- DOI
- 10.4143/crt.2021.1083
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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