Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 홍근 | * |
dc.date.accessioned | 2022-10-27T16:31:40Z | - |
dc.date.available | 2022-10-27T16:31:40Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2077-0383 | * |
dc.identifier.other | OAK-32225 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262783 | - |
dc.description.abstract | Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (<60 mL/min/1.73 m(2)), examining liver recipients with functionally intact kidneys one month after grafting using nationwide cohort data. Baseline risk factors were analyzed with multivariable Cox regression analyses and post-transplant risk factors were investigated with the time-dependent Cox model and matched analyses of time-conditional propensity scores. Of the 2274 recipients with a one-month eGFR >= 60 mL/min/1.73 m(2), 494 (22.3%) developed CKD during a mean follow-up of 36.6 +/- 14.4 months. Age, female sex, lower body mass index, pre-transplant diabetes mellitus, and lower performance status emerged as baseline risk factors for CKD. Time-dependent Cox analyses revealed that recurrent hepatocellular carcinoma (HR = 1.93, 95% CI 1.06-3.53) and infection (HR = 1.44, 95% CI 1.12-1.60) were significant post-transplant risk factors for CKD. Patients who experienced one of those factors showed a significantly higher risk of subsequent CKD compared with the matched controls who lacked these features (p = 0.013 for recurrent hepatocellular carcinoma, and p = 0.003 for infection, respectively). This study clarifies pre- and post-transplant non-renal risk factors, which lead to renal impairment after LT independently from patients' renal functional reserve. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | liver transplantation | * |
dc.subject | chronic kidney disease | * |
dc.subject | renal dysfunction | * |
dc.title | Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month | * |
dc.type | Article | * |
dc.relation.issue | 14 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | JOURNAL OF CLINICAL MEDICINE | * |
dc.identifier.doi | 10.3390/jcm11144203 | * |
dc.identifier.wosid | WOS:000833725600001 | * |
dc.author.google | Kim, Deok-Gie | * |
dc.author.google | Hwang, Shin | * |
dc.author.google | Kim, Jong Man | * |
dc.author.google | Ryu, Je Ho | * |
dc.author.google | You, Young Kyoung | * |
dc.author.google | Choi, Donglak | * |
dc.author.google | Kim, Bong-Wan | * |
dc.author.google | Kim, Dong-Sik | * |
dc.author.google | Nah, Yang Won | * |
dc.author.google | Kim, Tae-Seok | * |
dc.author.google | Cho, Jai Young | * |
dc.author.google | Hong, Geun | * |
dc.author.google | Yang, Jae Do | * |
dc.author.google | Han, Jaryung | * |
dc.author.google | Suh, Suk-Won | * |
dc.author.google | Kim, Kwan Woo | * |
dc.author.google | Jung, Yun Kyung | * |
dc.author.google | Moon, Ju Ik | * |
dc.author.google | Lee, Jun Young | * |
dc.author.google | Kim, Sung Hwa | * |
dc.author.google | Lee, Jae Geun | * |
dc.author.google | Kim, Myoung Soo | * |
dc.author.google | Lee, Kwang-Woong | * |
dc.author.google | Joo, Dong Jin|Korean Organ Transplantat Registry | * |
dc.contributor.scopusid | 홍근(55558687200) | * |
dc.date.modifydate | 20240429131310 | * |