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Bilateral Facial Weakness with Distal Paresthesia Following COVID-19 Vaccination: A Scoping Review for an Atypical Variant of Guillain-Barre Syndrome
- Title
- Bilateral Facial Weakness with Distal Paresthesia Following COVID-19 Vaccination: A Scoping Review for an Atypical Variant of Guillain-Barre Syndrome
- Authors
- Kim, Yoo-Hwan; Kim, Jee-Eun; Yoon, Byeol-A; Kim, Jong-Kuk; Bae, Jong-Seok
- Ewha Authors
- 김지은
- SCOPUS Author ID
- 김지은
- Issue Date
- 2022
- Journal Title
- BRAIN SCIENCES
- ISSN
- 2076-3425
- Citation
- BRAIN SCIENCES vol. 12, no. 8
- Keywords
- Guillain-Barre syndrome; COVID-19 vaccine; adverse effects; facial paralysis; systematic review
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Background and Purpose: Recent population-based studies from the US and UK have identified an increase in the occurrence of Guillain-Barre syndrome (GBS) following coronavirus disease 2019 (COVID-19) vaccination. However, the localized variant of GBS might be underestimated due to its rarity and atypical features. We aimed to identify and characterize bilateral facial weakness with distal paresthesia (BFWdp) as a GBS variant following COVID-19 vaccination. Materials and Methods: Relevant studies published during the COVID-19 pandemic were searched and identified in the MEDLINE, Embase, and other databases. Results: This review found that 18 BFWdp cases presented characteristics similar to previous BFWdp cases as defined in the literature: male dominance, frequent albuminocytological dissociation, and acute inflammatory demyelinating neuropathy pattern. In contrast, facial nerve enhancement on brain MRI and antiganglioside antibody positivity were often observed in BFWdp following COVID-19 vaccination. Conclusions: The mechanism of BFWdp following COVID-19 vaccination appears to be somewhat different from that of sporadic BFWdp. Neurological syndromes with rare incidence and difficulty in diagnosis should be considered adverse events of COVID-19 vaccination.
- DOI
- 10.3390/brainsci12081046
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
- Files in This Item:
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brainsci-12-01046-v2.pdf(467.3 kB)
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