Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유권 | * |
dc.contributor.author | 김태헌 | * |
dc.contributor.author | 김휘영 | * |
dc.contributor.author | 이민종 | * |
dc.contributor.author | 이혜아 | * |
dc.contributor.author | 전호수 | * |
dc.date.accessioned | 2022-08-12T16:31:42Z | - |
dc.date.available | 2022-08-12T16:31:42Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1542-3565 | * |
dc.identifier.issn | 1542-7714 | * |
dc.identifier.other | OAK-31969 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262522 | - |
dc.description.abstract | BACKGROUND & AIMS: International guidelines recommend physical activity for subjects with nonalcoholic fatty liver disease (NAFLD). This study investigated the association of physical activity with risk of liver fibrosis, sarcopenia, and cardiovascular disease (CVD) in NAFLD.METHODS: In this multicenter, retrospective study, 11,690 NAFLD subjects who underwent a health screening program and were assessed for physical activity (metabolic equivalent task [MET]-min/week) between 2014 and 2020 were recruited. Liver fibrosis was assessed by using the fibrosis-4 index, NAFLD fibrosis score, and FibroScan-AST score, sarcopenia by using multi -frequency bioelectric impedance analysis, and CVD risk by using atherosclerotic CVD (ASCVD) risk score, and coronary artery calcium (CAC) score were calculated.RESULTS: The prevalence of fibrosis, sarcopenia, high probability of ASCVD, and high CAC score signifi- cantly decreased with increasing quartiles of physical activity (all P for trend <.001). In a fully adjusted model, physical activity above 600 MET-min/week (& DDAG;third quartile) was indepen-dently associated with a reduced risk of fibrosis (adjusted odds ratio [aOR] = 0.59; 95% confidence interval [CI], 0.40-0.86), sarcopenia (aOR = 0.72; 95% CI, 0.58-0.88), high proba-bility of ASCVD (aOR = 0.58; 95% CI, 0.46-0.73), and high CAC score (aOR = 0.32; 95% CI, 0.13-0.83; all P <.05). In addition, increasing amounts of physical activity were significantly associated with risk reduction between fibrosis, sarcopenia, and high probability of ASCVD (all P for trend <.001). In subjects with sarcopenic obesity or lean NAFLD, physical activity was also independently associated with reduced risk of fibrosis and high probability of ASCVD (all P <.05).CONCLUSIONS: Physical activity showed a protective effect against fibrosis, sarcopenia, and CVD in NAFLD. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE INC | * |
dc.subject | Nonalcoholic Fatty Liver Disease | * |
dc.subject | Physical Activity | * |
dc.subject | Liver Fibrosis | * |
dc.subject | Sarcopenia | * |
dc.subject | Cardiovascular Disease | * |
dc.title | Association of Physical Activity With Risk of Liver Fibrosis , Sarcopenia, and Cardiovascular Disease in Nonalcoholic Fatty Liver Disease | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 358 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | * |
dc.identifier.doi | 10.1016/j.cgh.2021.12.043 | * |
dc.identifier.wosid | WOS:001030365400001 | * |
dc.identifier.scopusid | 2-s2.0-85125737359 | * |
dc.author.google | Chun, Ho Soo | * |
dc.author.google | Lee, Minjong | * |
dc.author.google | Lee, Hye Ah | * |
dc.author.google | Oh, Seo Yeong | * |
dc.author.google | Baek, Hyo Jeong | * |
dc.author.google | Moon, Jae Won | * |
dc.author.google | Kim, Yeon Jeong | * |
dc.author.google | Lee, Jinha | * |
dc.author.google | Kim, Hyoeun | * |
dc.author.google | Kim, Hwi Young | * |
dc.author.google | Yoo, Kwon | * |
dc.author.google | Kim, Tae Hun | * |
dc.author.google | Kim, Seung Up | * |
dc.contributor.scopusid | 유권(7202592827) | * |
dc.contributor.scopusid | 김태헌(57125156300;57219781484) | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.contributor.scopusid | 이민종(55917792000) | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.contributor.scopusid | 전호수(57215293394) | * |
dc.date.modifydate | 20240429140130 | * |