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Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database
- Title
- Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database
- Authors
- Kim J.-E.; Park J.; Min Y.G.; Hong Y.-H.; Song T.-J.
- Ewha Authors
- 송태진; 박진; 김지은
- SCOPUS Author ID
- 송태진; 박진; 김지은
- Issue Date
- 2022
- Journal Title
- Journal of the Peripheral Nervous System
- ISSN
- 1085-9489
- Citation
- Journal of the Peripheral Nervous System vol. 27, no. 3, pp. 206 - 214
- Keywords
- COVID-19; Guillain-Barré syndrome; Guillain-Barré syndrome variants; SARS-CoV-2; vaccination
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Vaccinations against the severe acute respiratory syndrome coronavirus 2 which causes COVID-19 have been administered worldwide. We aimed to investigate associations of COVID-19 vaccination with the occurrence of Guillain-Barré syndrome (GBS). We explored potential safety signals regarding the development of GBS using disproportionality analyses to compare COVID-19 vaccination with all adverse drug reaction (ADR) reports and influenza vaccines reported to VigiBase. As of October 15, 2021, a total of 2163 cases (0.13%) of GBS and its variants (including 46 cases of Miller-Fisher syndrome and 13 cases of Bickerstaff's encephalitis) were identified in entire ADR database after vaccination with the ChAdOx1 nCoV-19 (AstraZeneca, Cambridge, UK) or the two messenger RNA-based COVID-19 (BNT162b2; Pfizer and BioNTech) or mRNA-1273; Moderna) vaccines. The median time to onset of GBS after vaccination was around 2 weeks. The ChAdOx1 nCoV-19 and two messenger RNA-based COVID-19 vaccines demonstrated a higher risk for GBS against entire database (information component [IC]025 = 1.73 reporting odds ratio [ROR]025 = 3.51; IC025 = 1.07, ROR025 = 2.22, respectively). When compared with influenza vaccines, neither the ChAdOx1 nCoV-19 nor mRNA-based vaccines were found to be associated with greater risks of GBS (IC025 = −1.84, ROR025 = 0.11; IC025 = −1.86, ROR025 = 0.06, respectively). Although potential safety signals associated with GBS COVID-19 vaccines have been identified, the risk of GBS from COVID-19 vaccines were low and did not surpass those of influenza vaccines; however, because of the heterogeneity of the sources of information in the WHO pharmacovigilance database, further epidemiological studies are warranted to confirm these observations. © 2022 Peripheral Nerve Society.
- DOI
- 10.1111/jns.12507
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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