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Application of 18F-FDG brain PET for survival prediction in a rat model of hanging-induced hypoxic brain injury
- Title
- Application of 18F-FDG brain PET for survival prediction in a rat model of hanging-induced hypoxic brain injury
- Authors
- Kim D.; Lee W.J.; Lee H.W.; Kim B.S.; Woo S.H.; Yoon H.-J.
- Ewha Authors
- 윤혜전
- SCOPUS Author ID
- 윤혜전
- Issue Date
- 2022
- Journal Title
- Annals of Nuclear Medicine
- ISSN
- 0914-7187
- Citation
- Annals of Nuclear Medicine vol. 36, no. 6, pp. 570 - 578
- Keywords
- Asphyxia; Brain injuries; Fluorodeoxyglucose F18; Positron emission tomography computed tomography; Prognosis
- Publisher
- Springer Japan
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Accurate prediction of survival outcomes after hanging is a crucial and challenging issue in comatose survivors. In this preclinical study, we evaluated the potential utility of using brain glucose metabolism as measured by fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for survival prediction in a rat model of hanging-induced hypoxic brain injury (HBI). Methods: HBI was induced by mechanical hanging using Sprague Dawley rats. 18F-FDG brain PET images were acquired in 26 HBI rats three hours post-injury (3 h post-injury) and 4 controls. During the 1 month follow-up period, HBI rats were further classified as survivors (n = 15) and nonsurvivors (n = 11). Between-group regional (standardized uptake values normalized to the reference whole brain = SUVRWB, cerebellum = SUVRCB, and pons = SUVRpons) and voxel-based analyses were performed. The prognostic value of the SUVR was tested for overall survival (OS). In addition, diffusion-weighted imaging (DWI) was performed in 2 controls and 5 HBI rats (3 survivors, 2 nonsurvivors, 3 h post), and an apparent diffusion coefficient (ADC) map was generated. Results: The nonsurvivor group showed a significantly lower SUVRWB, SUVRCB, and SUVRpons of the cerebral cortices than the survivor group (all p < 0.001). Voxel-based comparison also demonstrated significant reduction in the nonsurvivor group compared with the survivor group (family-wise error-corrected p < 0.05). However, there was no significant difference between controls and survivors. Of 3 reference regions, the SUVRpons demonstrated the largest difference between the survivor and nonsurvivor groups. With an optimal cutoff value of 1.12 (AUC 0.952, p < 0.001), the SUVRpons predicted survival outcomes with a sensitivity of 81.8% and specificity of 100%. The OS of the low SUVRpons group was significantly shorter than that the high SUVRpons group (p < 0.001). The mean ADC values of each brain region showed no significant difference according to survival outcomes. Conclusions: These results suggest the potential utility of 18F-FDG brain PET for predicting survival in hanging-induced HBI. © 2022, The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.
- DOI
- 10.1007/s12149-022-01738-4
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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