NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
공과대학
화공신소재공학과
Journal papers
View : 421 Download: 0
Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate
Title
Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate
Authors
Park W.H.
;
Lee J.
;
Kim H.J.
;
Joo K.I.
;
Cha H.J.
Ewha Authors
주계일
SCOPUS Author ID
주계일
Issue Date
2022
Journal Title
Chemical Engineering Journal
ISSN
1385-8947
Citation
Chemical Engineering Journal vol. 446
Keywords
Complex coacervate
;
Dual drug-in-bioadhesive
;
Full-thickness skin grafting
;
Mussel adhesive protein
;
Wound healing process
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Conventional skin grafting procedures such as suturing and stapling are accompanied by pathologic scarring with functional and psychological sequelae; severe scars need a prolonged recovery period, increasing the chance of wound infections or graft contraction. The present study develops a novel bioadhesive delivering dual drugs to minimize scar formation and accelerate wound healing during full-thickness skin grafting. The bioadhesive is prepared via coacervation of a mussel protein and shows high adhesive strength in both porcine skin and in vivo rodent models; furthermore, it sustainably releases dual drugs (allantoin and epithelial growth factor) to enhance re-epithelialization and collagen deposition while simultaneously reducing scar formation. The proposed dual-drug-in-bioadhesive coacervate may ideally meet the requirements of the wound healing process and is a promising candidate for sutureless full-thickness skin grafting. © 2022 Elsevier B.V.
DOI
10.1016/j.cej.2022.137272
Appears in Collections:
공과대학
>
화공신소재공학과
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject