Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신상훈 | * |
dc.date.accessioned | 2022-07-19T16:30:58Z | - |
dc.date.available | 2022-07-19T16:30:58Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2772-3747 | * |
dc.identifier.other | OAK-31766 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261561 | - |
dc.description.abstract | Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411) © 2022 The Authors | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.subject | atherosclerosis | * |
dc.subject | coronary computed tomography angiography | * |
dc.subject | hemoglobin | * |
dc.title | Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels | * |
dc.type | Article | * |
dc.relation.issue | 3P2 | * |
dc.relation.volume | 2 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 311 | * |
dc.relation.lastpage | 319 | * |
dc.relation.journaltitle | JACC: Asia | * |
dc.identifier.doi | 10.1016/j.jacasi.2021.10.010 | * |
dc.identifier.scopusid | 2-s2.0-85132151640 | * |
dc.author.google | Won K.-B. | * |
dc.author.google | Lee B.K. | * |
dc.author.google | Heo R. | * |
dc.author.google | Park H.-B. | * |
dc.author.google | Lin F.Y. | * |
dc.author.google | Hadamitzky M. | * |
dc.author.google | Kim Y.-J. | * |
dc.author.google | Sung J.M. | * |
dc.author.google | Conte E. | * |
dc.author.google | Andreini D. | * |
dc.author.google | Pontone G. | * |
dc.author.google | Budoff M.J. | * |
dc.author.google | Gottlieb I. | * |
dc.author.google | Chun E.J. | * |
dc.author.google | Cademartiri F. | * |
dc.author.google | Maffei E. | * |
dc.author.google | Marques H. | * |
dc.author.google | de Araújo Gonçalves P. | * |
dc.author.google | Leipsic J.A. | * |
dc.author.google | Lee S.-E. | * |
dc.author.google | Shin S. | * |
dc.author.google | Choi J.H. | * |
dc.author.google | Virmani R. | * |
dc.author.google | Samady H. | * |
dc.author.google | Chinnaiyan K. | * |
dc.author.google | Berman D.S. | * |
dc.author.google | Narula J. | * |
dc.author.google | Bax J.J. | * |
dc.author.google | Min J.K. | * |
dc.author.google | Chang H.-J. | * |
dc.contributor.scopusid | 신상훈(7403646689;27868133100) | * |
dc.date.modifydate | 20240426130307 | * |