Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김충기 | * |
dc.date.accessioned | 2022-07-14T16:30:59Z | - |
dc.date.available | 2022-07-14T16:30:59Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2297-055X | * |
dc.identifier.other | OAK-31661 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261515 | - |
dc.description.abstract | Background: It is unclear whether beta-blocker treatment is advantageous in patients with stable coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). We evaluated the clinical impact of long-term beta-blocker maintenance in patients with stable CAD after PCI with drug-eluting stent (DES). Methods: From a nationwide cohort database, we identified the stable CAD patients without current or prior history of myocardial infarction or heart failure who underwent DES implantation. An intention-to-treat principle was used to analyze the impact of beta-blocker treatment on long-term outcomes of major adverse cardiovascular events (MACE) composed of cardiovascular death, myocardial infarction, and hospitalization with heart failure. Results: After stabilized inverse probability of treatment weighting, a total of 78,380 patients with stable CAD was enrolled; 45,746 patients with and 32,634 without beta-blocker treatment. At 5 years after PCI with a 6-month quarantine period, the adjusted incidence of MACE was significantly higher in patients treated with beta-blockers [10.0 vs. 9.1%; hazard ratio (HR) 1.11, 95% CI 1.06-1.16, p < 0.001] in an intention-to-treat analysis. There was no significant difference in all-cause death between patients treated with and without beta-blockers (8.1 vs. 8.2%; HR 0.99, 95% CI 0.94-1.04, p = 0.62). Statistical analysis with a time-varying Cox regression and rank-preserving structure failure time model revealed similar results to the intention-to-treat analysis. Conclusions: Among patients with stable CAD undergoing DES implantation, long-term maintenance with beta-blocker treatment might not be associated with clinical outcome improvement. | * |
dc.language | English | * |
dc.publisher | FRONTIERS MEDIA SA | * |
dc.subject | percutaneous coronary intervention | * |
dc.subject | coronary artery disease | * |
dc.subject | beta-blocker | * |
dc.subject | drug-eluting stents | * |
dc.subject | treatment outcome | * |
dc.title | Long-Term Beta-Blocker Therapy in Patients With Stable Coronary Artery Disease After Percutaneous Coronary Intervention | * |
dc.type | Article | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | FRONTIERS IN CARDIOVASCULAR MEDICINE | * |
dc.identifier.doi | 10.3389/fcvm.2022.878003 | * |
dc.identifier.wosid | WOS:000805786900001 | * |
dc.author.google | Lee, Seung-Jun | * |
dc.author.google | Choi, Dong-Woo | * |
dc.author.google | Kim, Choongki | * |
dc.author.google | Suh, Yongsung | * |
dc.author.google | Hong, Sung-Jin | * |
dc.author.google | Ahn, Chul-Min | * |
dc.author.google | Kim, Jung-Sun | * |
dc.author.google | Kim, Byeong-Keuk | * |
dc.author.google | Ko, Young-Guk | * |
dc.author.google | Choi, Donghoon | * |
dc.author.google | Park, Eun-Cheol | * |
dc.author.google | Jang, Yangsoo | * |
dc.author.google | Nam, Chung-Mo | * |
dc.author.google | Hong, Myeong-Ki | * |
dc.contributor.scopusid | 김충기(55697727500) | * |
dc.date.modifydate | 20240422141740 | * |