Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송태진 | * |
dc.contributor.author | 박진 | * |
dc.contributor.author | 김동엽 | * |
dc.date.accessioned | 2022-07-13T16:30:02Z | - |
dc.date.available | 2022-07-13T16:30:02Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2076-393X | * |
dc.identifier.other | OAK-31703 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261476 | - |
dc.description.abstract | Systemic capillary leak syndrome (SCLS) is a rare and potentially life-threatening disorder characterized by reversible plasma extravasation and vascular collapse. This study aimed to investigate the association between different types of COVID-19 vaccine and SCLS in a real-world setting. We used individual case safety reports of SCLS after COVID-19 vaccination from the WHO pharmacovigilance database, VigiBase. A disproportionality analysis of ChAdOx1 nCoV-19 and mRNA-based vaccines was performed. The information component (IC) and reporting odds ratio (ROR) were calculated from the entire database and viral vaccines data subset. A positive 95% lower end of the IC (IC025) value (>0) using Bayesian neural network analysis and lower end of the ROR 95% confidence interval (ROR025) >= 1 were defined as the ADR signal detection threshold. A total of 101 (0.004%) events of SCLS were identified. A significant potential signal of disproportionality of SCLS was noted in ChAdOx1 nCoV-19 when applied as the denominator for entire database (IC025 = 0.24, ROR025 = 1.23) and all viral vaccines (IC025 = 0.41, ROR025 = 1.59). No significant potential signal was noted for two mRNA-based vaccines as denominators for the entire database (IC025 = -0.49, ROR025 = 0.71) and all viral vaccines (IC025 = -0.32, ROR025 = 0.77). Contrary to ChAdOx1 nCoV-1, no safety signal for developing SCLS was identified for mRNA-based vaccines. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | SARS-CoV-2 | * |
dc.subject | COVID-19 vaccination | * |
dc.subject | adenoviral vector vaccine | * |
dc.subject | mRNA-based vaccine | * |
dc.subject | systemic capillary leak syndrome | * |
dc.title | A Disproportionality Analysis for Association of Systemic Capillary Leak Syndrome with COVID-19 Vaccination Using the World Health Organization Pharmacovigilance Database | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 10 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | VACCINES | * |
dc.identifier.doi | 10.3390/vaccines10060835 | * |
dc.identifier.wosid | WOS:000816309500001 | * |
dc.identifier.scopusid | 2-s2.0-85131420047 | * |
dc.author.google | Park, Jin | * |
dc.author.google | Kim, Dongyeop | * |
dc.author.google | Song, Tae-Jin | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.contributor.scopusid | 박진(57209628952) | * |
dc.contributor.scopusid | 김동엽(57192235701) | * |
dc.date.modifydate | 20240318140943 | * |