Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김휘영 | * |
dc.date.accessioned | 2022-06-02T16:32:28Z | - |
dc.date.available | 2022-06-02T16:32:28Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1542-3565 | * |
dc.identifier.issn | 1542-7714 | * |
dc.identifier.other | OAK-31532 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261391 | - |
dc.description.abstract | BACKGROUND & AIMS: Antiviral treatment from hepatitis B envelope antigen (HBeAg)-positive status may attenuate the integration of hepatitis B virus DNA into the host genome causing hepatocellular carcinoma (HCC). We investigated the impact of HBeAg status at the onset of antiviral treatment on the risk of HCC. METHODS: The incidence of HCC was evaluated in Korean patients with chronic hepatitis B who started entecavir or tenofovir in either HBeAg-positive or HBeAg-negative phase. The results in the Korean cohort were validated in a Caucasian PAGE-B cohort. RESULTS: A total of 9143 Korean patients (mean age, 49.2 years) were included: 49.1% were HBeAg-positive and 49.2% had cirrhosis. During follow-up (median, 5.1 years), 916 patients (10.0%) developed HCC. Baseline HBeAg positivity was not associated with the risk of HCC in the entire cohort or cirrhotic subcohort. However, in the non-cirrhotic subcohort, HBeAg positivity was independently associated with a lower risk of HCC in multivariable (adjusted hazard ratio [aHR], 0.41; 95% confidence interval [CI], 0.26-0.66), propensity score-matching (aHR, 0.46; 95% CI, 0.28-0.76), and inverse probability weighting analyses (aHR, 0.44; 95% CI, 0.28-0.70). In the Caucasian cohort (n = 719; mean age, 51.8 years; HBeAg-positive, 20.3%; cirrhosis, 34.8%), HBeAg-positivity was not associated with the risk of HCC either in the entire cohort or cirrhotic subcohort. In the non-cirrhotic subcohort, none of the HBeAg-positive group developed HCC, although the difference failed to reach statistical significance (aHR, 0.21; 95% CI, 0.00-1.67). CONCLUSIONS: This multinational cohort study implies that HBeAg positivity at the onset of antiviral treatment seems to be an independent factor associated with a lower risk of HCC in patients with chronic hepatitis B without cirrhosis, but not in those with cirrhosis. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE INC | * |
dc.subject | Cumulative Incidence | * |
dc.subject | DNA | * |
dc.subject | Hepatitis B Virus | * |
dc.subject | Liver Cancer | * |
dc.subject | Neoplasm | * |
dc.title | Impact of HBeAg on Hepatocellular Carcinoma Risk During Oral Antiviral Treatment in Patients With Chronic Hepatitis B | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1343 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | * |
dc.identifier.doi | 10.1016/j.cgh.2021.09.001 | * |
dc.identifier.wosid | WOS:000832942000021 | * |
dc.identifier.scopusid | 2-s2.0-85119065401 | * |
dc.author.google | Jang, Heejoon | * |
dc.author.google | Yoon, Jun Sik | * |
dc.author.google | Park, Soo Young | * |
dc.author.google | Lee, Han Ah | * |
dc.author.google | Jang, Myoung-Jin | * |
dc.author.google | Kim, Seung Up | * |
dc.author.google | Sinn, Dong Hyun | * |
dc.author.google | Seo, Yeon Seok | * |
dc.author.google | Kim, Hwi Young | * |
dc.author.google | Kim, Sung Eun | * |
dc.author.google | Jun, Dae Won | * |
dc.author.google | Yoon, Eileen L. | * |
dc.author.google | Sohn, Joo Hyun | * |
dc.author.google | Ahn, Sang Bong | * |
dc.author.google | Shim, Jae-Jun | * |
dc.author.google | Jeong, Soung Won | * |
dc.author.google | Cho, Yong Kyun | * |
dc.author.google | Kim, Hyoung Su | * |
dc.author.google | Nam, Joon Yeul | * |
dc.author.google | Lee, Yun Bin | * |
dc.author.google | Kim, Yoon Jun | * |
dc.author.google | Yoon, Jung-Hwan | * |
dc.author.google | Zoulim, Fabien | * |
dc.author.google | Lampertico, Pietro | * |
dc.author.google | Dalekos, George N. | * |
dc.author.google | Idilman, Ramazan | * |
dc.author.google | Sypsa, Vana | * |
dc.author.google | Berg, Thomas | * |
dc.author.google | Buti, Maria | * |
dc.author.google | Calleja, Jose Luis | * |
dc.author.google | Goulis, John | * |
dc.author.google | Manolakopoulos, Spilios | * |
dc.author.google | La Janssen, Harry | * |
dc.author.google | Papatheodoridis, George, V | * |
dc.author.google | Lee, Jeong-Hoon | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.date.modifydate | 20240429140130 | * |