Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준범 | * |
dc.date.accessioned | 2022-06-02T16:31:18Z | - |
dc.date.available | 2022-06-02T16:31:18Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.other | OAK-31372 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261281 | - |
dc.description.abstract | Purpose: The incidence of stroke and/or systemic thromboembolism (SSE) has not been properly evaluated in well-anticoagulated atrial fibrillation (AF) patients. This study investigated the incidence of SSE according to CHA2DS2-VASc score in contemporary well-anticoagulated Korean AF patients. Materials and Methods: From the prospective multicenter COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry, we identified 9503 patients with non-valvular AF (mean age, 68±8 years; female 35.5%) enrolled between June 2016 and May 2020 with eligible follow-up visits. Stroke incidence in the CODE-AF registry was compared with that in an oral anticoagulant (OAC)-naïve AF cohort from the Korean National Health Insurance database. Results: The usage rates of OACs and antiplatelet agents were 73.5% (non-vitamin K OACs, 56.4%; warfarin, 17.1%) and 23.8%, respectively. During a mean follow-up period of 26.3±9.6 months, 163 (0.78 per 100 person-years) patients had SSE. The incidence rate (per 100 person-years) of SSE was 0.77 in the total population, 0.26 in low-risk patients [CHA2DS2-VASc score 0 (male) or 1 (female)], and 0.88 in high-risk patients (CHA2DS2-VASc score ≥2). Contemporary AF patients had a stroke rate that was about one-fifth the stroke rate reported in a Korean OAC-naïve AF cohort. In this cohort, most risk factors for CHA2DS2-VASc score showed significant associations with SSE. Female sex was not associated with an increased risk of stroke/SSE in well-anticoagulated AF patients. Conclusion: Contemporary AF patients have a stroke rate about one-fifth that in OAC-naïve AF patients and exhibit different stroke risk factors. Study Registration: ClinicalTrials.gov (NCT02786095). © 2022, Yonsei University College of Medicine. All rights reserved. | * |
dc.language | English | * |
dc.publisher | Yonsei University College of Medicine | * |
dc.subject | Atrial fibrillation | * |
dc.subject | embolism | * |
dc.subject | risk | * |
dc.subject | stroke | * |
dc.title | Stroke and Systemic Thromboembolism according to CHA2DS2-VASc Score in Contemporary Korean Patients with Atrial Fibrillation | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 63 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 317 | * |
dc.relation.lastpage | 324 | * |
dc.relation.journaltitle | Yonsei Medical Journal | * |
dc.identifier.doi | 10.3349/ymj.2022.63.4.317 | * |
dc.identifier.wosid | WOS:000778154900002 | * |
dc.identifier.scopusid | 2-s2.0-85127288547 | * |
dc.author.google | Lee K.B. | * |
dc.author.google | Kim T.-H. | * |
dc.author.google | Park J. | * |
dc.author.google | Park J.-K. | * |
dc.author.google | Kang K.-W. | * |
dc.author.google | Kim J. | * |
dc.author.google | Park H.W. | * |
dc.author.google | Choi E.-K. | * |
dc.author.google | Kim J.-B. | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Shim J. | * |
dc.author.google | Joung B. | * |
dc.contributor.scopusid | 박준범(55131469900) | * |
dc.date.modifydate | 20240429132147 | * |