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Association between the fatty liver index and the risk of severe complications in COVID-19 patients: a nationwide retrospective cohort study
- Title
- Association between the fatty liver index and the risk of severe complications in COVID-19 patients: a nationwide retrospective cohort study
- Authors
- Chang Y.; Jeon J.; Song T.-J.; Kim J.
- Ewha Authors
- 송태진; 장윤경
- SCOPUS Author ID
- 송태진; 장윤경
- Issue Date
- 2022
- Journal Title
- BMC Infectious Diseases
- ISSN
- 1471-2334
- Citation
- BMC Infectious Diseases vol. 22, no. 1
- Keywords
- COVID-19; Fatty liver index; Mechanical ventilation; Non-alcoholic fatty liver; Prognosis
- Publisher
- BioMed Central Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Research on the association of non-alcoholic fatty liver disease (NAFLD) with prognosis in COVID-19 has been limited. We investigated the association between the fatty liver index (FLI), a non-invasive and simple marker of NAFLD, and the severe complications of COVID-19 patients in South Korea. Methods: We included 3122 COVID-19-positive patients from the nationwide COVID-19 cohort dataset in South Korea between January and June 2020. The FLI was calculated using triglyceride, body mass index, glutamyl transpeptidase, and waist circumference, which were obtained from the national health screening program data. Severe complications related to COVID-19 were defined as the composite of mechanical ventilation, intensive care unit treatment, high-oxygen flow therapy, and death within 2 months after a COVID-19 infection. We performed a multivariate logistic regression analysis for the development of severe complications in COVID-19 patients. Results: The mean ± standard deviation of FLI were 25.01 ± 22.64. Severe complications from COVID-19 occurred in 223 (7.14%) patients, including mechanical ventilation in 82 (2.63%) patients, ICU admission in 126 (4.04%), high-flow oxygen therapy in 75 (2.40%), and death in 94 (3.01%) patients, respectively. The multivariate analysis indicated that the highest tertile (T3) of FLI was positively associated with severe complications from COVID-19 (adjusted odds ratio (OR): 1.77, 95% confidence interval (CI) (1.11–2.82), P = 0.017) compared with the lowest tertile (T1). Conclusions: Our study demonstrated that FLI, which represents NAFLD, was positively associated with an increased risk of severe complications from COVID-19. FLI might be used as a prognostic marker for the severity of COVID-19. © 2022, The Author(s).
- DOI
- 10.1186/s12879-022-07370-x
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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