View : 470 Download: 0
Clinical Implications of Atrial Fibrillation Detection Using Wearable Devices in Patients With Cryptogenic Stroke (CANDLE-AF) Trial: Design and Rationale
- Title
- Clinical Implications of Atrial Fibrillation Detection Using Wearable Devices in Patients With Cryptogenic Stroke (CANDLE-AF) Trial: Design and Rationale
- Authors
- Jung, Sodam; Lee, Hye Ah; Kang, In Sook; Shin, Sang Hoon; Chang, Yoonkyung; Woo Shin, Dong; Park, Moo-Seok; Kim, Young Dae; Nam, Hyo Suk; Heo, Ji Hoe; Kim, Tae-Hoon; Yu, Hee Tae; Lee, Jung Myung; Heo, Sung Hyuk; Woo, Ho Geol; Park, Jin-Kyu; Roh, Seung-Young; Kim, Chi Kyung; Lee, Young-Soo; Do, Jin Kuk; Kim, Dong-Hyeok; Song, Tae-Jin; Park, Junbeom
- Ewha Authors
- 박준범; 송태진; 장윤경; 이혜아; 신상훈; 강인숙; 김동혁; 박무석; 신동우; 정소담
- SCOPUS Author ID
- 박준범; 송태진; 장윤경; 이혜아; 신상훈; 강인숙; 김동혁; 박무석
- Issue Date
- 2022
- Journal Title
- FRONTIERS IN CARDIOVASCULAR MEDICINE
- ISSN
- 2297-055X
- Citation
- FRONTIERS IN CARDIOVASCULAR MEDICINE vol. 9
- Keywords
- atrial fibrillation; wearable device; single-lead ECG; rhythm monitoring; ischemic stroke; cryptogenic stroke
- Publisher
- FRONTIERS MEDIA SA
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Although many electrocardiography wearable devices have been released recently for the detection of atrial fibrillation (AF), there are few studies reporting prospective data for wearable devices compared to the strategy of the existing guidelines in the detection of atrial fibrillation (AF) after cryptogenic stroke. A tiny single-patch monitor is more convenient than a conventional Holter monitor recording device and, therefore, longer duration of monitoring may be acceptable.& nbsp;& nbsp;Methods and Design: The CANDLE-AF study is a multicenter, prospective, randomized controlled trial. Patients with transient ischemic attack or ischemic stroke without any history of AF will be enrolled. The superiority of the 72-h single-patch monitor to standard strategy and non-inferiority of the 72-h single-patch monitor to an event-recorder-type device will be investigated. Single-patch monitor arm will repeat monitoring at 1, 3, 6, and 12 months, event-recorder-type arm will repeat monitoring twice daily for 12 months. The enrollment goal is a total of 600 patients, and the primary outcome is the detection of AF which continues at least 30 s during study period. The secondary outcome is the rate of changes from antiplatelet to anticoagulant and major adverse cardiac and cerebrovascular events within 1 year.& nbsp;Conclusions: The results of CANDLE-AF will clarify the role of a single-lead patch ECG for the early detection of AF in patients with acute ischemic stroke. In addition, the secondary outcome will be analyzed to determine whether more sensitive AF detection can affect the prognosis and if further device development is meaningful. ( KCT0005592).
- DOI
- 10.3389/fcvm.2022.837958
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML