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Efficient Production of Naringin Acetate with Different Acyl Donors via Enzymatic Transesterification by Lipases
- Title
- Efficient Production of Naringin Acetate with Different Acyl Donors via Enzymatic Transesterification by Lipases
- Authors
- Baek Y.; Lee S.; Son J.; Lee T.; Oh J.-M.; Lee S.H.; Kim H.U.; Seo S.W.; Park S.J.; Yoo H.Y.; Park C.
- Ewha Authors
- 박시재
- SCOPUS Author ID
- 박시재
- Issue Date
- 2022
- Journal Title
- International Journal of Environmental Research and Public Health
- ISSN
- 1661-7827
- Citation
- International Journal of Environmental Research and Public Health vol. 19, no. 5
- Keywords
- Acylation; Antioxidant; Enzymatic synthesis; Flavonoid; Flavonoid acetate; Flavonoid ester; Lipase; Naringin; Transesterification
- Publisher
- MDPI
- Indexed
- SCIE; SSCI; SCOPUS
- Document Type
- Article
- Abstract
- Naringin, one of the citrus flavonoids and known as a natural antioxidant, has limited bioavailability owing to its low stability and solubility. However, naringin esters formed via acylation have recently been reported to possess improved physical and chemical properties. The development of these compounds has a great potential in the food, cosmetic and pharmaceutical industries, but low conversion and productivity are barriers to industrial applications. This study aimed to improve the conversion of naringin acetate, which is formed via the enzymatic reaction between naringin and an acyl donor. An optimal reaction condition was determined by evaluating the effect of various variables (enzyme type, enzyme concentration, acyl donor, molar ratio of reactants, reaction temperature, and solvent) on the synthesis of naringin acetate. The optimal condition was as follows: 3 g/L of Lipozyme TL IM, molar ratio of 1:5 (naringin:acyl donor), reaction temperature of 40◦ C, and acetonitrile as the reaction solvent. Under this condition, the maximum conversion to naringin acetate from acetic anhydride and vinyl acetate was achieved at approximately 98.5% (8 h) and 97.5% (24 h), respectively. Compared to the previously reported values, a high conversion was achieved within a short time, confirming the commercial potential of the process. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/ijerph19052972
- Appears in Collections:
- 공과대학 > 화공신소재공학과 > Journal papers
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